The Value Of Electroencephalogram In Prognostic Assessment Of Neonatal Hypoxic-ischemic Encephalopathy

Objective: Depending on retrospective analysis, we reviewed the changing of electroencephalogram (EEG) for neonatal hypoxic-ischemic encephalopathy (HIE).To explor the value of EEG in prognostic assessment of neonatal HIE.Methods:286 cases of fullterm neonates with HIE in neonatology department of our hospital from March 2005 through March 2009 were studied and classified into different degrees of HIE. Early EEG had been made. The other examination items were carried out to synthetically evaluate the relationship of the organ damage rate of the neonates with EEG in the recent period and analyze abnormal rate of the EEG. After 2 weeks of treatment, follow-up of EEG and MDI, PDI Scoring were carried out separately in 3 and 6 months, and finally evaluate the relationship of EEG and prognosis of HIE.Results:(1)The abnormal EEG rate was 94.06% for the total cases (286/269), among which,90.5% (152/168) for the mild HIE,98.73% (78/79) for the moderate HIE, and 100% (39/39) for the severe HIE. (2)The organ damage rate in recent period was 6.67% for the neonates with normal EEG,18.7% for the neonates with mild abnormal EEG and 76.23% for the neonates with severe abnormal EEG(P<0.01). (3)The results of EEG of follow-up in three months is positively related to MDI and PDI scoring, namely the worse the EEG, the lower scoring of the indexes, that means the worse prognostic effects. The results of EEG of follow-up in six months is positively related to MDI scoring (P<0.05) and not significant related to PDI scoring.Conclusions:EEG can reflect functions of the neonates' brains. EEG is of relatively high value in the evaluating prognosis for the neonates with HIE. The worse the early EEG, the worse the prognosis of HIE. EEG is a non-invasive and sinple method and can be repeated in dynamic observation, thus worth to popularize in clinic.