Serum Anti-müllerian Hormone(AMH) Level In Healthy Reproductive Age Women

Anti-Mullerian hormone(AMH) as a regulator of female reproductive physiology has been closely concerned currently. AMH is produced by granulose cells in small growth follicles of ovary,and involved in follicular growth and development. The changes of serum AMH level with aging is the same as ovarian reserve.AMH is associated closely with ovarian function. Studies have shown that serum AMH level can actually reflect the female endocrine status in reproductive age better that conventional ovarian testing,such as follicle stimulating hormone(FSH),estradiol(E2)or luteinizing hormone(LH).Therefore,AMH is expected to become a new marker for assessment of ovarian function. At present there is no international reference value. Domestic research on AMH is less and there is no AMH normal value of large sample.In view of AMH and its clinical application advantages, it is necessary to learn the level of serum AMH levels in internal reproductive age women. We measured serum AMH levels throughout the menstrual cycle and reproductive age in domestic women, expected to provide information for clinical application.[Objective]This study by investigate the serum AMH levels in domestic normal reproductive age women, for further to provide information for clinical application.[Methods]A total of 100 healthy reproductive age women participated in this study,we divided the objects into two groups,follicular phase group and the luteal phase group. Blood samples were measured by AMH ELISA,and to compare AMH level between the two groups.On this basis,we divided the objects into different groups according to age,got AMH value in different reproductive age women. All data input statistical software for analysis.[Results]1.Median serum AMH levels in the follicular phase group is 2.78±1.65ng/ml, and the luteal phase group is 3.06±1.78 ng/ml, Serum mean AMH levels were no statistically significantly in each group. 2.AMH level is 2.85±1.66 ng/ml of 100 healthy women in reproductive age. Serum AMH level is as high as 4.25±1.23ng/ml between 18 to 25 year-old female,then decline with increasing age,and drop significantly between 41 to 47 year-old,which average level is 1.12±0.98 ng/ml. Linear correlation analysis shows that the AMH levels were negatively correlated to age(r=-0.667,P<0.001).[Conclusion]1.Serum AMH levels do not change significantly in the follicular phase and luteal phase of the menstrual cycle,we can detect AMH in any day of menstrual cycle.2.Serum AMH levels decline with age, and negatively correlated to age. The clinical application of AMH need consideration of the age.3.AMH is a marker for evaluating ovarian function.