Study On Renal Perfusion Of Patients With Liver Cirrhosis By Contrast-enhanced Ultrasound

Objective:To access the renal perfusion of hepatocirrhosis at different levels in patients by contrast-enhanced ultrasound with time-intensity curve, For the early detection of abnormalities of renal perfusion to provide basis for clinic.Methods:Thirty patients of hepatocirrhosis, According to Child-Pugh classification of liver function were divided into:Child-Pugh A class, Child-Pugh B class and Child-Pugh C class; thirteen normal controls. Maximal long-axis cross-section image of renal was acquired by 2D ultrasound and then contrast-enhanced ultrasound (MI=0.07) was performed on right kidney. Renal perfusion was analyzed quantitatively with the time-intensity curve by QontraXt software. The parameters of the time intensity curve include time to peak intensity (TP), peak signal intensity (Peak), sharpness and area under the curve (AUC). Investigate the changes of blood perfusion and time-intensity curve parameters in hepatocirrhosis at different Levels.Results:â‘ In contrast to control group, the cirrhosis group showed decreased blood perfusion in the renal cortex and an reduced perfusion rate, with significantly lower peak intensity, extension of time to peak, and decreased area under the curve (P<0.01). Sharpness in the renal cortex of the two groups had no significant difference (P>0.05).â‘¡In the comparison of renal cortex quantify parameters between normal group and three cirrhosis groups, there were no difference between Child-Pugh A class and normal group (P>0.05). The peak intensity and area under the curve were significantly decreased in Child-Pugh B class and especially in C class (P<0.01). Compared to Child-Pugh A class and normal group, time to peak increased in Child-Pugh B class and C class(P<0.01). There were no difference between Child-Pugh B class and C class (P>0.05)Conclusions:Contrast-enhanced ultrasound combined with time-intensity curve can analyze renal perfusion of hepatocirrhosis quantitatively at different Levels. The change of the parameters of the time intensity curve closely related to the degree of cirrhosis. For the early detection of abnormalities of renal perfusion to provide basis for clinic, The reduction of renal perfusion was earlier than the changes of routine laboratory indexes in hepatocirrhosis.