| Objective:To investigate the changes in the thyroid function of the in-patients with coronary heart disease(CHD) and and its relationship with dyslipidemia in euthyroid patients with CHD.Methods:Levels of free thyroxine (FT4),free triiodothyronine (FT3),and thyoid stimulating hormone (TSH) were measured by electrochemiluminescence (ECL) and levels of total cholesterol (TC) and low density lipoprotein-cholesterol (LDL-C) were determined by Beckman automated biochemical analyzer in 111 patients with CHD and 96 normal controls.23 patients with thyroid disease were excluded and the remaining 88 euthyroid patients with CHD compared with the normal control.Then the 88 patients were divided into 3 groups by the TSH value and compared the prevalence of dyslipidemia in different TSH levels.Results:20.72% of the CHD patients in hospital were present with thyroid dysfunction, in which 4 cases were hyperthyroidism,2 cases were subclinical hyperthyroidism,10 patients were hypothyroidism and 7 cases were subclinical hypothyroidism.Subjects belonging to the CHD group showed lower mean FT3 level compared with the controls. The prevalence of hypercholesterolemia was higher in the group C than others in CHD patients.Conclusion:1.The incidence of thyroid dysfunction in the CHD patients is high.2.Our results show that the levels of FT3 were lower in euthyroid patients with CHD than that of normal controls, consistent with hormonal findings found in the "euthyroid sick syndrome (ESS)" in which FT3 is markedly reduced.3. There were correlationships between the prevance of dyslipidemia and thyroid hormones levels in CHD patients with thyroid dysfunction, however no general rule in euthyroid patients with CHD.4. The clinical implications of this study were related to a better knowledge of the role of thyroid hormone metabolism in nonthyroidas systemic illnesses, such as coronary heart disease. For these reasons, thyroid hormone levels should be evaluated in patients with CHD or even suspected CHD. |
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