Correlative Analysis Of Subclinical Hypothyroidism And Dyslipidemia

Purpose:To investigate the correlation between subclinical hypothyroidism and dyslipidemia and to provide theoretical basis for the prevention of cardiovascular events in subclinical hypothyoidism cases.method:This study evaluated 2230 subjects with normal thyroid function and248 cases with subclinical hypothyroidism in the First Hospital of Jilin University from September 2014 to December 2014.Subjects’ age range18 to 85 years old,and sex ratio is 1: 1.Participants in this study comprised healthy subjects without known systemic disease,not taking any medication that may reduce blood lipid and affect thyroid function.Subjects with a history of thyroid dysfunction(hyperthyroidism or hypothyroidism)and pregnant were excluded from this study after detailed review.Data collected included age,sex,height,weight,body mass index,waist circumference,pulse rate,and systolic/diastolic blood pressure.Laboratory data included thyroid function tests,fasting glucose level,lipid profile.Participants were classified into subclinical hypothyroidism,subclinical hyperthyroidism,and euthyroid groups according to thyrotropin levels.result:1.In the whole population,The detection rate of subclinical hypothyroidism was 10.0%,and was presented in women was higher than that of men(13.13% vs 7.42%),the difference was statistically significant(χ2 = 21.7 P = 0.000,P <0.05).All cases grouped according to age and sex,the detection rate of subclinical hypothyroidism of male weresignificantly lower than the female in all age groups(P <0.05).In the group of 60-69 years,the subclinical hypothyroidism is presented in men is 10.0% and 24.0% in women,were higher than other age groups.In the whole population,the incidence of subclinical hypothyroidism was gradually increasing with age(trend test χ2 = 8.90,P = 0.00).2.Basic clinical characteristics of subjects with SCH and control were appeared in Table 2.The sex,age,thyroglobulin antibody,BMI,glycosylated hemoglobin,triglyceride,total cholesterol,low density lipoprotein cholesterol among cases are significantly different from controls(P <0.05).After adjustment for confounding factors which affect the lipids,the TSH level was independent of gender,age,height and BMI was positively correlated with triglyceride levels(male r = 0.13,female r = 0.20,P <0.01).Markly,compared with the group with TSH levels less than 4.2mmIU/l,4.2 <TSH <10mmIU/L and TSH≥10mmIU/L,the risk for hypertriglyceridemia increased approximately 1.97-fold and4.96-fold(OR = 1.97,P = 0.004;OR = 4.96,P = 0.002).Who suffering from subclinical hypothyroidism has 2.01 times and 2.49 times as euthyroid subjects risk for hypertriglyceridemia in men and women respectively(OR=2.01,P=0.002;OR=2.49,P = 0.000).In addition,TSH levels were positively correlated with TC and LDL in women(TC:r=0.08,LDL:r=0.09;P < 0.01).Compared with euthyroid female subjects,the risk for TC abnormality and LDL abnormality were 1.51-fold and 1.82-fold in SCH women(P < 0.05),we also explored the realtionship between other serum lipid parameters and TSH in men,although the differences were not statistically sigbificant.3.Compared with the normal thyroid function,the positive rate of TPOAb、TgAb and TPOAb/TgAb is higher in patients with subclinical hypothyroidism(P=0.000).All sub-ects were divided into TPOAb+/Tg Ab-,TgAb+/TPOAb-,TPOAb+/TgAb+,TPOAb-/TgAb-four groups,according to whether antibody is positive,there is no significant differe nce in serum lipids parameters between four groups(P > 0.05),but the risk for TPOAb+/TgAb-group occurred in hypercholesterolemia is1.69 times as the TPOAb-/TgAb-group,(OR=1.69,95% Cl:1.07-2.71,P< 0.05).After adjustment for confounfers such as TSH,TPOAb is positively associated with LDL levels in subclinical hypothyroidism cases(r=0.15,P=0.04).conclusion:1.The incidence of subclinical hypothyroidism was significantly higher than male,In the whole population the incidence of subclinical hypothyroidism was gradually increasing with age.The detection rate of subclinical hypothyroidism in male were significantly lower than the female in all age groups.In the group of 60-69 years,the subclinical hypothyroidism is presented in men is 9.8% and 26.5% in women,were higher than other age groups.2.Subclinical hypothyroidism can significantly increase triglyceri de levels.TSH >10mIU/L is the highest risk for hypertriglyceridemia.Compared with euthyroid subjects,SCH cases are more prone to o ccur LDL and TC abnormals in women.3.Compared with the normal thyroid function,the positive rate of TPOAb、TgAb and TPOAb/TgAb is higher in patients with subclinical hypothyroidism.There was a positive correlation between TPOAb and low density lipoprotein in subclinical hypothyroidism cases.It has not been found that thyroid autoantibodies independent of thyroid function were associated with dyslipidemia.