The Detections Of IL-2 And CD4~+CD28~-T Lymphocyte In Patients With ST-segment Elevation Myocardial Infarction And Atorvastatin Pretreatment Before Primary Percutaneous Coronary Intervention

Objective:The purpose of this study was to explore the differences of levels of CD4+CD28- T lymphocytes and Interleukin-2(IL-2) in peripheral vein blood and infarct-related coronary artery (IRA) in patients with ST-segment elevation myocardial infarction. And we investigated the influence of atorvastatin 80mg administered to patients with STEMI before primary PCI on levels of CD4+ CD28-T lymphocytes and IL-2 both in peripheral vein blood and IRA and their ventricular function 14 days after PCI.Methods:Included 56 patients with STEMI who accepted primary PCI. All patients were assigned into atorvastatin group and control group randomly. All of them were pretreated with aspirin (300 mg orally) and clopidogrel (600 mg as a loading) just before PCI. Atorvastatin group (n=31) took 80mg atorvastatin while control group (n=25) took placebo. Blood samples were obtained from the peripheral vein and IRA during PCI. The proportion of CD4+CD28-T lymphocytes in blood was tested by flow cytometry, and concentrations of IL-2 in plasma of the peripheral vein blood and IRA were measured by enzyme-linked immunosorbent assay. The hemodynamic indexes of ventricular function by Acoustic QuantifIRAtion (AQ) were measured as follow:LA, LV and LVEF.Results:(1) Comparison within group:The levels of IL-2 and CD4+CD28- T lymphocytes were signifiantly higher in IRA than peripheral vein blood in two groups. (P＜0.05)(2) Comparison between groups:the level of IL-2 decreased signifiantly in atorvastatin group compared with control group both in IRA and peripheral vein blood (P＜0.05). The levels CD4+CD28-T lymphocytes had no difference between two groups. (P＞0.05)(3) The data of LVEF, LV and LA in atorvastatin group didn't increased signifiantly compared with control group 14 days after PCI (P＞0.05)Conclusions:The levels of IL-2 and CD4+CD28-T lymphocytes were signifiantly higher in IRA than peripheral vein blood in patients with STEMI. Administered atorvastatinto just before PCI could lower the levels of inflammatory markers in patients with AMI, while the early administration of atorvastatin had no more beneficial in ventricular function in short term.