| Objective:To respectively examine the efficacy of intravenously injected lidocaine, epidurally administered lidocaine/ropivacaine on 3ED95 cisatracurium-induced neuromuscular block.Methods:Sixty patients were randomly assigned to one of four study groups. every patient was neuromuscular blocked with 0.15 mg/kg cisatracurium and monitored with acceleromyographic train-of-four (TOF) monitor at the flexor pollicis brevis. Intravenous lidocaine group (VL group) intravenously inject 2%lidocaine 1.5 mg/kg at the time of 15 min before induction and continuously inject with the 0.03 mg/(kg·min) rate. Epidural anesthesia was performed 15 min before induction on epidural lidocaine group (EL group) and epidural ropivacaine group (ER group). The EL group was given a bolus of 1.5 mg/kg of 2%lidocaine and 3.3 mg/kg after an hour. Compared to the EL group, the ER group was given the same volume of 0.5% ropivacaine. Disappearance of T1, return of T2 and T3 were recorded.Results:Disappearance of T1 in the VL group was shorter than the control group (C group) 1.73±1.29min (P<0.05). Time course of the return of T2 in the VL and EL group was respectively 9.57±6.31 and 8.97±6.40min longer than the C group (P<0.05). Time course of the recovery of T3 in the VL and EL group was respectively 10.23±6.25 and 9.35±6.39min longer than the C group (P<0.05). The three time courses did not differ significantly between the ER and the C group (P<0.05).Conclusions:Intravenous lidocaine reduces the onset time of cisatracurium, Intravenous or epidural lidocaine extends its clinical duration. But epidural ropivacaine has no influence on its neuromuscular blockade.
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