Analysis Of The Clinic And Prognostic Factors In Patients After Primary Cytoreductive Surgery For Advanced Epithelial Ovarian Carcinoma

The incidence of ovarian cancer in the female reproductive tract cancers in third place in the female genital tract tumors contributed to the cause of death in patients with the highest of a tumor, has advanced, refractory, relapse rate and poor prognosis features.Ovarian cancer according to the origin of cell types(epithelial,stromal or germ cell)classification.Most ovarian cancer from ovarian(85%-95%),or epithelial ovarian tumors. According to histological type(serous,mucinous, endometrioid,clear cell) can be further broken down.Epithelial ovarian cancer according to FIGO staging criteria. This involves advanced epithelial ovarian cancer,FIGO stageâ…¡-â…£.The incidence of ovarian cancer is worldwide each year. The number is more than 140,000.National incidence rates were different.In the UK,ovarian cancer ranks the fourth place of common female cancer incidence rate,is the primary death cause of gynecologic oncologic oncology,women's lifetime cancer risk If 2%. In the UK,incidence of the 5174 people in 1988,6880 people in 1998. In some countries the incidence of ovarian cancer stabilized in the more affluent countries such as Finland,Denmark,New Zealand,the United States, the incidence rate is falling.This study retrospectively analyzed 86 patients with advanced epithelial ovarian cancer in Dalian Gynecology & Obstetrics Hospital,combined therapy,and explore advanced refractory ovarian cancer theatment modalities. Objective To investigate the clinical features treatment and prog-nostic factors of patients with advanced epithelial ovarian carcinomaMethods 86 patients with advanced epithelial ovarian carcinoma in Dalian Gynecologic and Obstetrical Hospital from April 2002 to April 2007 were retrospectively reviewed.The data were analyzed statistically by SPSS 17.0.Kaplan-Meier method to calculate the survival time.Cox proportional hazards regression model was used to determine the effect of each variable on prognosis.Results The median age was 45 years and the median survival time was 38.54-45.46 months.Pathologica stage (FIGO2000):â…¡a3 cases (3.49%),â…¡b5 cases(5.81%),â…¡c7 cases(8.14%),â…¢a 21 cases (24.42%),â…¢b3 cases(3.49%),â…¢c of 40 cases(46.51%),â…£7 cases(8.14%).Pathological classification:serous cystadenocarcinoma,56 cases(65.12%),mucinous cyst-adenocarcinoma in 4 cases(4.65%),endometrial carcinoma,6 cases(6.98%), clear cell carcinoma in 7 cases(8.14%),poorly differentiated adeno-carcinoma in 9 cases(10.47%),mixed carcinoma in 3 cases(3.49%),Brenner tumor 1(1.16%).Histological grade:well-defferentiated 2 cases, differen-tiated 29 cases,55 cases of poorly defferentiated.Ascites cancer cells were detected in 20 cases.53 cases with lymph node metastasis.All 86 patients received initial cytoreductive surgery in the treatment of patients with chemotherapy alone,79 patients received intravenous chemotherapy,7 received intraperitoneal infusion combined with intravenous chemotherapy. Multivariate analysis showed that the prognosis of patients with ovarian cancer,radical surgery of(P<0.01),pathological stage(P<0.05)and number of chemotherapy treatment(P<0.01 correlation.Conclusion To enhance therapeutic efficacy and prolong the survival time of patients with advanced epithelial ovarian carcinoma,the key points are completeness of excision,Clear pathological stage and standard plus enough courses of postoperative chemotherapy.