Lizhixiao Capsule Lipid-Lowering FAT Consumption Lipid Lowering High Flood Chole Steriol In Rats

Objective: Observations made fat away lipid-lowering Wistar rats blood capsule in the fall hematic fat action. Explore made fat away lipid-lowering capsules against experimental hyperlipidemia mechanism. Preliminary research made fat away lipid-lowering capsule of security. Methods: 1. Through the biggest drug test for mice, observation made fat away lipid-lowering capsule may produce acute toxicity reaction. Opposition fat away lipid-lowering medication safety capsule.2. Through the copy dietary hyperlipidemia model, adopt colorimetric method observation made fat away lipid-lowering 0.4 g/low dose capsule, dose GMBH &co, 0.8 g/high doses of 1.6 g/kg, continuous to medicine for 15 days, hyperlipidemia animal model of serum total cholesterol (TC) and triglycerides (TG), high-density lipoprotein (HDL - C), low density lipoprotein cholesterol (L), - And hyperlipidemia animal model of liver homogenate total cholesterol (TC) and triglycerides (TG) content.Results: 1. The biggest drug tests to mice: Made fat away with the highest concentrations of cholesterol-lowering capsule (50%), the biggest drug volume (0.4 ml / 10g), 1 to 24 hours. For maximum dosage for 20g/kg and it is equivalent to clinical dosage of 291 times. In all, the mice live 7d. Mice are in good condition. Did not appear any discomfort phenomenon. Fur, activities, normal, normal, diarrhea. After 7 days,death animals and gross anatomy. Macroscopic observation heart, liver, lienal lung and kidney, major organs, Compared with controls,look not seen changes. Results shows made fat away lipid-lowering low toxicity capsule.2 Hyperlipidemia model: Compared with placebo, high fat feed rats fed high fat feed 3 weeks, TC, serum level of TG significantly increased (P < 0.01).3 The influence of blood: Made fat away lipid-lowering capsule group and low doses of high dose group, could significantly reduce hyperlipidemia model animal serum TC, LDL - C and TG content.Compared with the model group (P < 0.01), And can improve hdl-c content(P < 0.01). Made fat away lipid-lowering capsule that hyperlipidemia animal model of liver TC and TG decline, P < 0.01.Conclusion: Made fat away lipid-lowering capsule acute toxicity.Clinical application is safe. The drugs significantly lower cholesterol and improve hepatic steatosis. Prevention and treatment of hyperglycemia in development of hepatic steatosis has positive significance.