The Correlational Study Of Type 2 Diabetes Cognitive Dysfunction And TCM Syndrome Type And Homocysteine

Objective:To study the correlation between cognitive impairment and. syndrome types of Traditional Chinese Medicine (TCM) and homocysteinemia (Hcy) of Type 2 Diabetes Mellitus (T2DM), and the relationship between hyperhomocysteinemia (HHcy) and syndrome types of TCM, to discuss the related dangerous factors of cognitive impairment and HHcy. Provide references for preventing and intervening cognitive impairment of T2DM by TCM. Methods:58 cases of T2DM inpatients were choosen as T2DM group and 30 cases of healthy volunteers were choosen as control group. Evaluate cognitive function by Clinical Memory Scale(CMS) and Mini-Mental State Examination(MMSE) and complete the serum Hcy concentration test and routine laboratory test. Establish TCM symptom rating scale to divide T2DM group into 3 basic patterns of syndrome and 3 accompanied patterns syndrome, and calculate the points of each pattern of syndrome. Results:(1) The incidence rate of cognitive impairment of T2DM group was obviously higher to control group. There was Statistic difference between the two groups(χ2= 13.387, P<0.001). The Memory Quality (MQ) and scores of each memory test were obviously lower to control group. There were statistic differences between the two groups(P<0.05-0.01). (2) The MQ was related to syndrome differentiation and classification of TCM in T2DM group. (3) The serum Hey concentration of T2DM group was higher than control group. There was Statistic difference between the two groups (P<0.01). The serum Hcy concentration was related to syndrome differentiation and classification of TCM. (4) There were Statistic differences of the serum Hcy concentration in control group, normal cognitive function group of T2DM and cognitive impairment group of T2DM(P<0.05-0.01). (5) There were Linear correlations in MQ, total score of TCM syndrome and serum Hcy concentration. (6) There were statistic differences in total score of TCM syndrome, course of diseases, HbAlc, triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), apolipoprotein B(ApoB), Hcy, systolic blood pressure(SBP) between normal cognitive function group of T2DM and cognitive impairment group of T2DM (P<0.05). Statistic difference of other factor was not found. There were Linear correlations in MQ, course of disease, TG, TC, HDL-C, HbAlc, SBP of T2DM patients. Related relationship of other factor was not found. (7) Blood urea nitrogen (BUN), creatinine (Cr) of high Hcy group of T2DM were higher than those of normal Hcy group of T2DM. There were Statistic differences between the two groups (P<0.05). In T2DM group, serum Hcy concentration has Linear correlations with BUN and Cr. Correlation coefficients were respectively(r=0.25,0.343, P<0.05). Serum Hcy concentration has no related relationship with other factors. (8) There were statistic differences in TG, ApoB, Hcy, HDL-C, MQ, total score of TCM symptom between deficiency-excess complex pattern group and simple deficiency group (P<0.05-0.01). Other outcomes had no statistic differences between the two groups. Conclusion:(1) T2DM patients have cognitive impairment and HHcy, and the both are related to syndrome types of TCM. (2) HHcy is probably a risk factor of cognitive impairment of T2DM. (3) The concentration of Hcy of T2DM patients were related to BUN and Cr and HHcy was probably related to dysfunction of kidney in T2DM patients.