| Chinese medicine is a treasure of Chinese nation, in the prevention, care, regulate body functions, etc., there is no substitute for the role of synthetic drugs. According to the World Health Organization, 80% of the population around the world in the use of traditional Chinese medicine, However, heavy metal pollution in recent years, traditional Chinese medicine to the international market as a serious obstacle to the development of Chinese medicine.Heavy metals can cause nervous system, digestive system, respiratory system, circulation system toxicity; our country on the lead, cadmium, copper, arsenic, mercury and other heavy metals provided the total limit standard.Statistics of the current status of pollution and found that: most Chinese have a certain amount of heavy metals, some quite serious overweight; excessive severity is Cd> Hg> Pb> As> Cu; Cd's excessive rate of 26.3%.Get rid of heavy metals are present method of supercritical CO2 extraction, macroporous resin sequestration technologies, flocculation method.Inorganic ions has not yet been found in resins used in Chinese medicine get rid of heavy metals reported in the literature.To understand the commercial heavy metal pollution in Chinese medicine, screening for 15 commonly used Chinese medicine, the use of graphite furnace atomic absorption spectrometry of lead and cadmium by flame atomic absorption determination of copper content. Analysis of the test results we get: Tongxinluo copper content of 32.25mg.kg-1, lead content of 16.937 mg.kg-1, cadmium content of 0.589 mg.kg-1; Sang Ju cold tablets of cadmium The content of 0.3685 mg.kg-1. These are beyond China in 2001 formulated by the Ministry of Foreign Trade and Cooperation, "the import and export of medicinal plants and preparation of green industry standards." Pharmacopoeia reference to the basis of the establishment of 15 Chinese herbs Copper, Lead and cadmium content of the method, by comparing the wet digestion and dry ashing sample treatment found that TXL dilution determination of copper in a number of times the measured value of the wet digestion 0.9μg. g-1 higher than the dry ashing 0.69μg.g-1; Lead Determination dry ashing 358ng.g-1 measured value is higher than the wet digestion using PTEE 305 ng.g-1; adding 10% nitric acid dissolution of dry ash digestion, determination of lead is 365 ng.g-1 did not decrease, the determination of the value of copper has increased 0.91μg.g-1; choose dry ashing, acid method is more suitable for Copper, Lead and Cadmium Atomic medicine Determination of absorption pre-treatment. Determination of cadmium values measured with dry ash values 9.7ppb, adding 10% nitric acid solution by the results of 10.6 ppb., Select the dry ashing, acid method is more suitable for Chinese Copper, Lead and Cadmium by Atomic Absorption Spectrometry Determination of the pre-treatment .To understand the commercial heavy metal pollution in Chinese medicine, screening for 15 commonly used Chinese medicine, the use of graphite furnace atomic absorption spectrometry of lead and cadmium by flame atomic absorption determination of copper content. Analysis of the test results we get: Tongxinluo copper content of 32.25mg.kg-1, lead content of 16.937mg/kg of cadmium content of 0.589 mg/kg; SangJu cold tablets of cadmium content of 0.3685. These values are beyond the cooperation of the Ministry of Foreign Trade in 2001 formulated the《Import and Export of Medicinal Plants and Preparation of Green Industry Standards》. Pharmacopoeia reference to the basis of the establishment of 15 Chinese herbs Copper, Lead and Cadmium content of the method, by comparing the wet digestion and dry ashing sample treatment found that the determination of wet digestion of copper measured values 0.9μg/g higher than the dry Ashing 0.69μg/g; Lead determination dry ashing 358ng/g measured value is higher than the wet digestion using PTEE 305 ng/g; dissolved in nitric acid with 10% of dry ash digestion , Determination of lead is 365 ng/g did not decrease, the determination of the value of copper has increased 0.91μg/g; choose dry ashing, acid method is more suitable for Copper, Lead and Cadmium in Chinese atomic absorption spectrometry determination of prior treatment. Determination of cadmium values measured with dry ash values 9.7ppb, adding 10% nitric acid solution by the results of 10.6 ppb., select the dry ashing, acid method is more suitable for Chinese Copper, Lead and Cadmium by Atomic Absorption Spectrometry Determination of the pre-treatment .High content of selected heavy metals Tongxinluo capsule technology as an inorganic ion resin rid study Tongxinluo capsule Yiqihuoxue, Tongluozhitong effect, is commonly used in clinical cardiovascular and cerebrovascular diseases effective drugs; for Coronary Heart Disease angina, myocardial infarction, arrhythmia, myocardial ischemia diseases have a good effect; for cerebral infarction, cerebral ischemia, cerebral hemorrhage, stroke sequelae have a significant effect. HPLC method was established to determine the medicine Tongxinluo Paeoniflorin capsules, the USP using 70% methanol into a non-toxic ultrasonic treatment of 70% ethanol. Through the study found that the method is accurate, reliable, fast, easy, and determined by the method of Tongxinluo in paeoniflorin.Resin with inorganic ions in the copper Tongxinluo get rid of lead and cadmium in the experiment, to find an effective way to get rid of heavy metals: The TXL treated samples of inorganic ions on the resin column, the column before and after the determination of heavy metals and the active ingredients of these three Calculation of paeoniflorin Copper, Lead and cadmium content of the active ingredients drive out rate and recovery of paeoniflorin, the test found that the yield of the three resins paeoniflorin in excess of 95%, SIB-1 resin> SICu resin> SI-2 resin. SIB-1 resin, which after recovery 101.04%, SICu resin rid of 100% copper, is a valid drive out of copper material. SIB-1 resin is better than SI-2 resin, two resin rid of lead in more than 95%. Get rid of the three resin effects of cadmium is not good ,were below 85%. SIB-1 resin as the recovery and removal of paeoniflorin significant effect of lead, get rid of the resin for the three heavy metals of factors: alcohol eluant, temperature, PH value, eluent flow rate and other factors were investigated . The results showed that 70% ethanol, 1.5mL/min flow rate, 1.7 times the amount of resin, PH 6, temperature 25°C, the amount of eluent volume was 9 times the amount of resin was the best. |
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