The Expression Of Bradykinin B2 Receptor In Adenomyosis And The Relationship With Dysmenorrhea

Adenomyosis is a kind of multiple 35-45 years old of multiparous gynecological disease,according to reports in the womb of surgical resection specimen about 6% - 40% with adenomyosis, its specific pathogenesis is still failed to clarify, adenomyosis is considered one kind of endometriosis, uterus the basic pathologic changes for ectopic endometrium ovarian hormones influence, appear periodically bleeding, thus induce local inflammation. .Adenomyosis clinical manifestations includes progressive dysmenorrhea, menstrual disorders, infecund etc, especially dysmenorrhea seriously affect people's quality of life, the conservative treatment of the effect is not effective, which poses a challenge to medical workers. With the development of the molecular biology technology, appeared a lot for adenomyosis pathogenesis and its cause of progressive dysmenorrhea, makes various causes of dysmenorrhea related factors is put forward. Bradykinin is well researched mechanism of pain. In numerous inflammatory pain caused by medium of the inflammation, Bradykinin is an important one of a medium, it can radiosensitizing nociceptive neurons in pain, play an important role in the creation process, and whether adenomyosis is a kind of inflammatory factor mediated pain? By observing the expression of bradykinin B2 receptor in adenomyosis uterus specimen ,this experimen study the role of bradykinin B2 receptor in mechanism of adenomyosis .Bradykinin plays a major role in the pain conduction and adjust of nervous system, it also plays a role in cardiovascular system , respiratory system, the digestive systemBradykinin, say again relieve shock peptide,( abbreviation BK) is a kind of inflammation factor, mainly produces in hypoxia, when the body to produce inflammation, its original IP peptide receptor mainly distributed in smooth muscle cells, fiber cells, nerves cells again neurotransmitters plays a major role, bradykinin is a kind of aliphatic nine peptide, (Arg, Pro, Pro, Gly, Phe, Ser, Pro, Phe, Arg), is arouse peptide original on the exciting peptide release of enzymes, and the influence of the pancreatic slow shock peptide, a pancreatic shock peptide structure basic same, is different excitation peptide enzyme effects of product, slow by blood IP peptide IP peptide hydrolysis enzyme degradation by.Through various ion channels, promote ionic glutamate receptor or ATP - relevant sandblast ionic receptors, bradykinin can pass radiosensitizing pain receptors for pain control, knockout mice on the experiment of related receptors will be weakened the slow shock peptide inflammatory pain caused. In adenomyosis ,the expression of bradykinin B2 receptor increases, through a variety of receptors and channels to lead to dysmenorrhea produced, these channels can be sodium channels potassium ion channels. receptors promote ionic glutamate receptor or ATP - relevant sandblast ionic receptors.This experiment using immunohistochemistry research the bradykinin B2 receptor in 19 cases normal endometrium and muscular layer, 37 cases of adenomyosis in ectopic, ectopic lesions (including ectopic endometrium and its surrounding tissues) the expression. All cases exclude gynecological endocrine diseases, and in preoperative three months are unused hormonal contraception. Obtained biopsy firstly, and then HE dyeing in microscopically to sieve out has not seen the chronic inflammation change and not merge gynecological malignancy organization. This experiment data with the brief statistics software SPSS12.0 statistical analysis, and statistical treatment using t-test for binary comparison, when p value is less than 0.05, the results have statistical significance.As the research findings indicate, in the control group bradykinin B2 receptor is expressed in endometrial organization, but don't express , but compared to the experimental group, the control group intimal expression is low value state, explain bradykinin B2 receptor has close relationship with the adenomyosis, bradykinin can pass immune, promote ectopic endometrium formation of blood vessels, regulating cell apoptosis aspects to participate in the adenomyosis occurrence and development, while the dysmenorrhea group of adenomyosis from different groups within between experimental results comparison shows, with the increase of severity dysmenorrhea, the expression of bradykinin B2 receptor strengthens, in the womb glandular myopathy ectopic tissue of expression in reaches a certain threshold in just appear dysmenorrhea performance, to illustrate that bradykinin in the adenomyosis may be caused by the expression dysmenorrhea factors.Anyhow, bradykinin B2 receptor plays an important role in the adenomyosis process and dysmenorrhea generation of adenomyosis patients, and it wil play an important role in treatments of adenomyosis and dysmenorrhea in future, and it needs further study...