| Curcumin, the main active component of rhizomes of Curcuma longa with the moiety ofβ-diketones function,has been discovered with number of biological activities such as antioxidant, wound-healing, antipyretic etc. Nowadays, attention has been focused on its antitumor activity for its safety and low side-effects. Although extensive studies have been done on curcumin, the structure-activity relationship and pharmacological profile have not been adequately evaluated. Herein, an efficient and convenient procedure for the synthesis and development new form of some curcumin analogues is necessary.The main contents are as follows:1.The effects of reaction time, reaction temperature and volume of catalyst on the yield of reactions between the aromatic aldehyde and 2, 4-pentanedione in the presence of monoethanolamine were studied and the optimal preparation conditions were obtained.2.The complexation of curcumin withβ-cyclodextrin, along with its stoichiometry, solubility and complexation constant were determined. Meanwhile, physical properties of the water soluble curcumin sodium was studied by ultraviolet-visible and fluorescent analysis.3.The formulation and quality assessment of two curcumin gels, prepared from carbomer and the wetting agents glycerin and propylene glycol were studied. The contents of drug within the gels were assayed by the ultraviolet spectrophotometry. Results show that the formulation of the gels were reasonable and their quality could be controlled. |
PDF Full Text Request