Research Clinicopathologic Features And Prognosis In Triple Negative Breast Cancer

Objective The aim of this study was to analyze the Clinicalpathol- ogic charcteristics, metastasis, survival and Prognostic factors of Triple-negative breast cancer.Methods Clinicapathologic data of 295 patients , and 45 patients were Triple-negative breast cancer. The Clinicapathologic Charcteristics, recurrence and survival of the patients were Analyzed.Results 15% all of breast cancers was TNBC. Compared to The non-TNBC, TNBC had larger tumor size ,advanced pathologic stage, more lymph node metastasis at diagnosis, higher mutation rate of p53 and recurrence rate. The 5-year disease free survival (DFS)and overall survival of TNBC were 48.9% and 71.1%, respetively. Simple fator analysis showed that tumor size ,lymph node status, pathologic stage and the mutation of p53 were found to be correlated with OS. Multivariate cox regression showed that lymph node status and the mutation of p53 were the independent fators influencing the prognosis of TNBC.Conclusion TNBC was characteristic of larger tumor size, more lymph node metastasis at diagnosis, advanced pathologic stage, higher mutation rate of p53 and recurrence rate, shorter survival time compared to the non-TNBC . The lymph node status and the mutation of p53 were the independent fators influencing the prognosis of TNBC.