Target-controlled Infusion Of Propofol With Remifentanil For Total Intravenous Infusion For Laparoscopic Cholecytectomy

Objective:To evaluate the anesthetic effect of total intravenous anesthesia(TIVA) with target-controlled infusion of propofol with remifentanil in the practice of laparoscopic cholecytectomy.Methods:The first group, twenty patients needing for laparoscopic cholecytectomy were anesthetized by total intravenous anesthesia(TIVA) with target-controlled infusion of propofol(4.0～2.Oug/ml) and remifentanil(5.0～2.0 ng/ml). The second group, twenty patients needing for laparoscopic cholecytectomy were anesthetized by total intravenous anesthesia(TIVA) with continous infusion of propofol(4～10 mg.kg-1.h-1) and remifentanil(5～22ug.kg-1.h-1).Mean artieral pressure(MAP),systolic blood pressure(SBP),diastolic blood pressure(DBP),heart rate(HR),pulse oxygen saturation (SpO2)were monitored contionously for twenty-three times.Results:SBP,DBP,MAP in group TCI were much lower than group CI(P<0.05).There were three patients vomiting,two tachycardia,one hypotension,one restles, zero hypertension in group TCI,while in group CI,four patients vomiting,ten tachycardia,seven hypotension,one restles, five hypertension.Conclusion:Compared with CI, total intravenous anesthesia(TIVA) with target-controlled infusion of propofol with remifentanil can provide better anesthetic effect in laparoscopic cholecytectomy. The proper drug concentration is propofol(4.0～2.Oug/ml) and remifentanil (5.0～2.0 ng/ml).