The Association Of The G894T Polymorphism Of ENOS Gene With The Decompression Effects And Glucose And Lipid Metabolism Of Telmisartan In Essential Hypertensive Patients In Dongxiang Minority Population In Gansu Province

Objective:This article mainly discusses the association of the G894T polymorphism of endothelial nitric oxide synthase (eNOS) gene with the decompression effects and glucose and lipid metabolism of telmisartan in essential hypertensive patients in Dongxiang minority population in Gansu province.Methods:1.214 healthy people and 270 patients with essential hypertension were enrolled in.2. To determine the index of Plasma fasting glucose, triglyceride, total cholesterol, high-density lipoprotein, Low density lipoprotein, blood serum uric acid and weight. after 2 weeks hypertension group placebo treatment, taking telmisartan drug for 4 weeks. Observe and record antihypertensive effects. Select 40 patients who meet the conditions with diabetes mellitus hypertension continued to take telmisartan to 10 weeks and to To determine the index of Plasma fasting glucose, triglyceride, total cholesterol, high-density lipoprotein, Low density lipoprotein, blood serum uric acid.3. application polymerase chain reaction-extinction enzymes fragment length polymorphism analysis. Gene polymorphism parting at 7theG894 T adopt nitrate reducing enzymatic determination serum nitric oxide metabolites (NOX) level,4. Gene frequency, allele frequency and between groups material compares the project x 2 inspection, measurement data results to mean±standard deviation, inspection standards of alpha=0.05.Results:1.eNOS gene G894T polymorphism accord with Weinberg balance law. EH group GT+ TT genotype and T allele frequency are higher than NT group (P=0.036, P=0.008), there is statistically significant in difference.2. EH group GT+genotype TT fasting serum NOX below GG genotype (P=0.013). there is statistically significant in difference.3. there is not statistically significant (P>0.05) to compared T alleles carriers of the systolic blood pressure and diastolic in EH group. after four weeks Treatment GG genotype carriers systolic blood pressure, diastolic pressure drops than T alleles carriers, differences are significant (P<0.05). After 10 weeks treatment,the number of 40 patients with diabetes mellitus listed hypertension, fasting glucose, triglicerids, high-density lipoprotein cholesterol (hdl-c), total cholesterol, low density lipoprotein, blood serum uric acid are obviously decreased than before,the difference was statistically significant (P< 0.05).Conclusion:T allele of eNOS 7th G894 T polymorphism involved in EH happen of Dongxiang people. T alleles carriers (298Glu-Asp) probably make NO product reduce participation EH incidence by Influence encoded eNOS activity.There is correlation between the G894T polymorphism of eNOS gene of hypertension and Telmisartan antihypertensive effects. G alleles carriers is superior to T alleles carriers on Telmisartan the antihypertensive effects, also can improve hypertension patients with diabetes mellitus glucolipid metabolism level.