A Study On The Relationship Between Genetic Polymorphisms Of Wnt-7a/rs1874626 And Nonsyndromic Cleft Lip With Or Without Cleft Palate In Gansu Province

Objective:To investigate the potential association SNP between rs 1874626 markers in Wnt-7a and the risk of human NSCL/P (nonsyndromic cleft lip with or without cleft palate).Methods:Case control study was used, the Department of Oral and Maxillofacial Surgery of The Second Hospital of Lanzhou University in Gansu patients rs 1874626 for study sites was selected during May 2009 and May 2010.110 NSCLP patients were selected as experimental group and 100 normal people were selected as control group.The genotype and gene frequency of Wnt-7a rs1874626 polymorphisms site was tested by flight mass spectrometry.Results:The nonsyndromic cleft lip with or without cleft palate patients gene frequencies was higher than normal children significantly (P< 0.05). For Wnt-7a Gene rs 1874626, the gene type and gene frequency between different type of Nonsyndromic cleft (NSCL/P) patients and healthy people was different. Nonsyndromic cleft (NSCL/P) patients significantly higher than normal group gene frequencies, difference was statistically significant (p< 0.05).Conclusion:We found that there are genetic polymorphisms of Wnt-7a/rs 1874626 in the people of Gansu Province of China, and it may be a risk factor for NSCL/P in Gansu province. There was no statistical significance between the cases with and without family history, but we need further research.