Expression And Clinical Significancen Of HMGB1,HE4 And CA125 In Epithelial Ovarian Carcinoma

Objective To study the relationship of high mobility group protein B1 (high mobility group box-1, HMGB1), human epididymal protein (human epididymis protein, HE4) and CA125 in epithelial ovarian cancer, and to analyse the expression and clinical significance in epithelial ovarian cancer.Methods The expression of HMGB1, HE4 and CA125 in serum were detected in 96 women by Enzyme linked Immunosorbent Assay(ELISA)) double antibody sandwich method. 66 hospitalized patients with pelvic masses from Gansu Provincial People's Hospital of Obstetrics and Gynecology were divided into 40 patients with benign ovarian tumors and 26 patients with ovarian cancer in accordance with pathological findings after surgery.30 healthy women from Gansu Provincial People's Hospital Medical Center were regarded as control group. To analyse the relationship of these results with development, invasion, metastasis and different stages, clinicopathological features in epithelial ovarian cancer. And to discuss the clinical significance of HMGB1, HE4 and CA125 as tumor markers in epithelial ovarian cancer.Results1. The expression of HMGB1, HE4 and CA125 was significantly higher than the other two groups in serum of epithelial ovarian cancer patients. There was significant difference (P<0.05). The expression of HMGB1, HE4 and CA125 in serum of ovarian benign tumor group was higher than the normal control group, but no significant difference (P> 0.05)2.The expression of HMGB1 in epithelial ovarian cancer patients with lymph node and distant metastasis was higher than those without metastasis, There was significant difference (P <0.05); The expression in patients with FIGO III-IV was higher than that of patients withⅠ-Ⅱ.There was significant difference (P<0.05)。The expression of HMGB1 in patients with different pathological types was different, but no significant difference (P> 0.05).3. The expression of HE4 in epithelial ovarian cancer with different stages and pathological types was difference, but no significant difference (P> 0.05).4. The sensitivity of HMGB1, HE4 and CA125 in epithelial ovarian cancer were 78.6%, 69.2%,80.8%,meanwhile the specificity were 60.2%,97.1%,77%. Conclusion1. The expression of HMGB1, HE4 and CA125 in epithelial ovarian cancer were higher than ovarian benign tumor group and control group, these factors may contribute to the identification of benign and malignant ovarian tumors.2. The expression of HMGB 1 was different in various stages of ovarian cancer and different pathological types. HMGB1 may correlate with development, invasion and metastasis of epithelial ovarian cancer, and may be a target gene for therapy of ovarian cancer.3. In epithelial ovarian cancer, CA125 had the highest sensitivity, HE4 had the highest specificity, therefore, it is more effective to combine them for screening and initial diagnosis in epithelial ovarian cancer.