The Plasma NT-ProBNP Level And Its Clinical Significance In Patients With Unstable Angina Pectoris Whoes Left Veniricular Systolic Dysfunction Were Nomarl

Objective: To investigate the change and clinical significance of Plasma N-terminal Pro-brain natriuretic pePtide(NT-ProBNP) concentrations and to evaluate whether NT-ProBNP was conform with the pathological damage and the influence of Percutaneous coronary intervention(PCl) on the NT–P- roBNP level in Patients with unstable angina Pectoris, whoes left veniricular systolic dysfunction were nomarl.Methods: 123 Patients whoes LVEF were highter more than 50% and no clinical of heart faliure were hos- pitalized in the department of cardiology of the osecond affiliated hospital of hebei medical university because of coronary heart disease confirmed by coronary angiograPhy(CAG), composing of 91 Patients with unstable angina pectoris(UAP) and 32 Patients with stable angina Pectoris(SAP). 32 healthy people from hospital outpatient service medical center whithout Heart, brain,anfd kidney disease were collected as control group. Plasma NT-ProBNPconcentrations were measured in all of the patents. All Patients undweent echocardiograPhy to evaluate the left ventrieular function by LVEF with color echocardiography apparatus of German SIEMENS-512 contermorary atfer taking blood for NT-ProBNP. Gensini score was counted according to result of coronal artery angiography(CAG). Analyzed the changer of NT-proBNP in eath groups,and explored the correlation between NT-proBNP and Gensini score.The changer of NT-proBNP before PCI and the third day were compared in unstable angina pectoris groups.Results: 1.There were no signifieant difference in UAP group ,SAP group and control group about general clinical data. 2. The level of NT-proBNP in patients was skewness distribution,but it was normal distribution after conversing with the logarit- hm(lg),and total variance was orderliness. Plasma NT-proBNP concertrations were increased in patients with UPA compared with those of SAP and control subject respectively, (2.38±0.15)vs(1.56±0.34) p=0.000( p<0.05),(2.38±0.15)vs(1.53±0.33),p=0.000( p<0.05). However,there was no signifieant difference betwee the patients with SAP and control subjects,(1.56±0 .34) vs(1.53±0.33)p=0.597( p>0.05).3.The level of NT-proBNP in patients with UPA correlated with Gensini score, r= 0.641,p<0.05. The LVEF with each of the subjects was highter more than 50%, there was no signifieant difference betwee the patients with UAP and SAP subjeets, (67.13±4.71)vs(66.14±4.61) p=0.30( p>0.05). 4. The level of NT-proBNP in patients with UAP increased gradually with the increasing of coronary lesions count, there was signifieant difference different among groups of the coronary lesions in patients with UAP.Plasma NT-proBNP level were highter in patients with multivessel disease than those of single lesion and souble teams lesions , (2.50±0.10)vs(2.39±0.10),p=0.00,( p<0.05)和(2.50±0.10)vs(2.24±0.13),p=0.044,( p<0.05);And there was signifieant difference betwee Single lesion group and Double teams lesions group, (2.24±0.13)vs(2.39±0.10),p=0.005,( p<0.05).5.Plasma NT-proBNP level were lower in each groups of different lesions in the third day after PCI comparing with before PCI , (2.19±0.15)v(s2.24±0.13)P=0.025,P<0.05 in single lesion group, (2.32±0.11)vs(2.39±0.10) P=0.020,P<0.05 in double teams lesions group and (2.37±0. 13)vs(2.50±0.10) P=0.000,P<0.05 in multivessel disease group.Conclusion: 1.Excepting Left ventricular systolic dysfunctio , the plasma level of NT-proBNP increased compared with those of SAP and control subject respectively,and had a positive correlation with coronary disease severity, the more severity of coronary disease,the more NT-proBNP . The reasons may be related with myocardial ischemia.2. Plasma NT-proBNP would relate recent curative effect of PCI and be a sensitive index to evaluate prognosis in patients with UAP who undwent PCI.