Serum Level Changes Of Pentraxin3 And S100A8/A9 And Its Correlation With Short-term Prognsis Of Patients With Acute Coronary Syndromes

Background:Acute coronary syndromes (ACS) was a group of clinical syndromes which characterized by acute myocardial ischemia, consists of acute myocardial infarction (AMI) and unstable angina pectoris (UAP). It is known that the inflammatory factors play a important role in the development of ACS (Acute coronary syndromes). Pentraxin3 and S100A8/A9 were found as two novel inflammatory factors of ACS. In our research, the serum levels were observed before and after treatment. The study also revealed the relationship between the levels and short-term prognosis, and discussed the clinical significance of pentraxin3 and S100A8/A9 on treatment and prognosis of ACS.Methods:126 patients of CHD include unstable angina pectoris (UAP,n=51), acute myocardial infarction (AMI,n=50), stable angina pectoris (SAP,n=25) and healthy people(NC, n=25) were enrolled in this study. Serum levels of PTX3 and S100A8/A9 were detected by ELISA on the day patients admitted into the hospital and after one week treatment. Serum levels of PTX3 and S100A8/A9 were compared in different ACS groups which were divided by the branch number of coronary artery stenosis.The short-term prognosis of patients with ACS were collected by phone follow-up after 3 months.Results:(1) Serum levels of PTX3, S100A8/A9 in UAP and AMI were significantly higher than SAP and healthy control group (P<0.05); The levels in SAP are also higher than the healthy control group (P<0.05); there were no significant difference between UAP and AMI (P>0.05). (2) After one week standard treatment, the serum levels of PTX3, S100A8/A9 in patients with ACS were significantly lower than at admission (P<0.01), but still higher than normal level of healthy controls (P<0.01); (3) Serum levels of PTX3 in two and three coronary lesions group were significantly higher than one coronary lesions group (P< 0.05); Serum levels of S100A8/A9 in three coronary lesions group were significantly higher than one and two coronary lesions group (P<0.05); (4) Short-term prognosis of patients with ACS was affected by PTX3,hs-CRP and TC (P<0.05), not by S100A8/A9 (P>0.05).Conclusions:Serum levels of PTX3 and S100A8/A9 were significantly elevated in patients with ACS. With the increase in the number of coronary lesion, serum PTX3, S100A8/A9 levels increased in patients with ACS. Increased serum PTX3 prompted poor short-term prognosis of patients with ACS.