To Study The Correlation Between Serum S100A8/A9,IL-1β Levels And Clinical Diagnosis And Prognosis Of Acute Coronary Syndrome

Objective: To investigate the clinical diagnostic and prognostic value of serum Ca2+ binding S100 protein A8/A9 and Interleukin-1β(IL-1β)in patients with acute coronary syndrome.Methods: A total of 320 patients with chest pain who underwent coronary angiography in the First Affiliated Hospital of Bengbu Medical College from June 2019 to September 2020 were selected.According to their history of present disease,angiography results,and clinical biochemical indicators,they were divided into an acute coronary syndrome group(ACS group,n=240)and a control group without obvious stenosis(CON group,n=80).The ACS group was further divided into a myocardial infarction group(AMI group,n=160)and an unstable angina pectoris group(UAP group,n=80).Baseline data and serological indicators were collected.1.Serum S100A8/A9 and IL-1β levels were measured and compared among the three groups by enzyme-linked immunosorbent assay,and baseline data and serological indicators were compared among the three groups.2.Based on the results of coronary angiography,ACS patients were divided into single-vessel disease group(n= 53,22.08%),double-vessel disease group(n= 59,24.46%)and multi-vessel disease group(n= 128,53.33%).3.The Gensini score of ACS patients was based on the results of coronary angiography,and the degree of coronary artery disease in each branch was calculated.The score was 1 for 25%,2 for 25%-50%,4 for 51%-75%,8 for 76%-90%,16 for91%-99%,and 32 for 100% occlusion.Multiplied by the correlation coefficient: 5 for the left main trunk;Circumflex artery lesions: 2.5 proximal,1 distal;The posterior collateral branch was 0.5;Posterior descending artery: 1;Lad lesions: 2.5 in proximal and 1.5 in middle;D1 was 1,D2 was0.5;1 for right coronary artery disease.The patients were divided into mild coronary stenosis group(0-27 points,49 cases,20.41%),moderate coronary stenosis group(28-50 points,62 cases,25.83%)and severe coronary stenosis group(> 50 points,129 cases,53.75%).Baseline data,serum S100A8/A9 and IL-1β levels were compared between the two groups.4.Patients with ACS were followed up for 10±2 months by telephone,and were divided into MACEs group and non-MACEs group according to the presence or absence of major adverse cardiovascular and cerebrovascular events(MACEs).Serum S100A8/A9 and IL-1β levels were compared between the two groups.ROC curve was drawn to evaluate the diagnostic value of serum IL-1β and S100A8/A9 for ACS.5.Binary Logistic analysis was used to analyze the influencing factors of MACCEs in ACS patients.Results: 1.The levels of serum S100A8/A9 and IL-1β in ACS group were significantly higher than those in control group(P < 0.05).2.Serum levels of S100A8/A9 and IL-1β in ACS patients,with the increase of the number of diseased vessels and Gensini score,IL-1β showed an upward trend.S100A8/A9 was significantly higher in the multi-vessel lesion group and the high Gensini score group than the other two groups,and S100A8/A9 was positively correlated with IL-1β level.3.The sensitivity and specificity of S100A8/A9 combined with IL-1β in the diagnosis of ACS are better than those of single detection,which has certain reference value for the diagnosis of ACS patients.4.Binary logistic regression analysis showed that S100A8/A9,IL-1β and cTnI were independently associated with MACEs in ACS patients.The results showed that S100A8/A9,IL-1β and cTnI were risk factors for MACEs in ACS patients.Conclusions: 1.The levels of serum S100A8/A9 and IL-1β are significantly increased in ACS patients,and they are positively correlated.2.S100A8/A9 and IL-1β combined diagnosis of ACS is more valuable than single diagnosis.3.Serum S100A8/A9 and IL-1β levels have certain predictive value for major adverse cardiovascular events in ACS patients.