Effect Of Yiqi Huayu Fang On The Expression Of Estrogen, Progest And Their Receptors In Rats Model Of Medical Abortion

objective:To explore the mechanism of Yiqi huayu fang in the role of uterine involution in rats model of medical abortion,by observing the content of E₂,P in serum and the expression of ER, PR in uterine tissues.Methods:Seventy-two SD pregnant rats were randomly devid-ed into 6 groups:blank group,model group,Chan fu kang group, Yiqi huayu fang low-,middle-,and high-dose group. Except the blank group,we make other five groups the model of medical abortion. The content of E₂,P in serum were detected by radioimmunoassay (RIA)and the expression of ER,PR in uteri-ne tissues by immunohistochemistry.Results:Both the content of E₂,P in serum and the expression of ER, PR in uterine tissues of the model group were lower than the blank group. Comparing with the model group,the content of E₂ raised and P reduced in Yiqi huayu fang low-, middle-,high-dose group with significant difference(P<0.05,P<0.01),and no statistical meaning with Chan fu kang group (P>0.05).The expression of ER and PR was raised in Yiqi Hua-yu fang middle dose group(P<0.05,P<0.01).The content of E₂,P and the expression of ER,PR in three groups of Yiqi Huayu Fang all have no significant difference(P>0.05).Conclusion:The content of E₂, P and the expression of ER, PR were reduced in the rats postpartum uterine redintegration incomplete model after medical abortion, that may impair the repair of endometrium. Yiqi Huayu Fang played a role in cur-ing uterine redintegration incomplete caused by medical aborttion,by raising the content of E₂,ER and PR,and reducing the content of P.