| OBJECTIVE To investigate the "reasonable" control of bedtime blood glucose in type 2 diabetic patients.METHODS A retrospective analysis was carried out to record bedtime blood glucose (BBG) and its following 24-hours fasting blood glucose (FBG),2 hours prand blood glucose (PBG2h) and mean blood glucose (MBG) in 2398 days of 500 patients with type 2 diabetes. To analyze the relationship between BBG and its following FBG, PBG2h and MBG.The patients were divided into groups by BBG or mean bedtime blood glucose (MBBG). And to study the difference of FBG, PBG2h and incidence of hypoglycemia in different bedtime blood glucose range.RESULTS BBG had relation with fasting, postdinner, postlunch and postbreakfast blood glucose by multiple linear regression analysis. Mean postdinner blood glucose (BG). mean FBG and mean postlunch BG showed more correlation with mean BBG than mean postbreakfast BG. When BBG>6.1,≤7.8mmol/L, FBG (7.00±1.75 mmol/L), postlunch BG (9.36±4.54mmol/L), postdinner BG (8.88±2.61 mmol/L), MBG (8.35±1.38 mmol /L) were well controlled and incidence of hypoglycemia was the lowest (nocturnal hypoglycemia 0.3%, day hypoglycemia 3.0%) compared with BBG<4.4 mmol/L,≥4.4, <6.1mmol/L (P<0.05). When MBBG> 6.1,<7.8mmol/L or>7.8,<9.5 mmol/L, mean FBG(7.00±1.18mmol/L,7.33±1.18mmol/L)and mean postdinner BG(8.51±1.62mmol/L,9.48±1.63 mmol/L) were well controlled, while incidence of hypoglycemia was lower (28.5％,22.6%) than that when MBBG≥4.4,≤6.1 mmol/L (P<0.05).Hypoglycemia incidence in non-insulin secretagogue oral antihyperglycemic group was the lowest (4.76%) compared with sulfonylureas (12.77%), insulin (26.14%) and insulin versus non-sulfonylureas oral antihyperglycemic group (15.82%) (P<0.05)CONCLUSIONS When BBG>6.1,≤7.8mmol/L and MBBG>6.1,<9.5mmol/L, its following 24-hours FBG, PBG2h were well controlled and incidence of hypoglycemia was the lowest. So the best range of BBG maybe is>6.1,≤7.8mmol/L in the patients with type 2 diabetic.
|
PDF Full Text Request