Resting State In Patients With Chronic Low Pain Under The Change Of Brain Functional Networks

ObjectivesChronic pain is dissipated in the acute tissue injury to last more than 1 month of pain, or repeated episodes of pain over 3 months. Central mechanism of pain is currently still not fully understood. In recent years, there have been several brain imaging techniques, including functional magnetic resonance imaging (functional magnetic resonance imaging, fMRI), magnetic resonance spectroscopy (magnetic resonance spectroscopy, MRS), single photon emission computed tomography (single-photon emission computed tomography, SPECT) and positron emission tomography (positron emission tomography, PET), these brain imaging technology to the field of pain research, the pathophysiology of pain mechanisms and treatment of research opened up more areas; Functional Magnetic Resonance (fMRI) is a noninvasive, convenient and, reflecting the advantages of the human body function in the inspection means pain has become one of the main research center. Studies have found that chronic pain is now in the etiology, pathological anatomy, pathophysiology, symptoms and other aspects and acute pain were significantly different, so both the diagnosis and treatment are also obvious differences. Currently used in functional imaging study of pain, mostly induced acute pain or acute pain model, less used in studies of chronic pain.MethodsSelected 15 patients with chronic low back pain patients and 16 healthy controls were resting state functional magnetic resonance imaging, the use of Siemens Avanto 1.5T MRI system, using the standard quadrature head coil.Head and axial magnetic resonance scan, locate cable in connection eyebrow level, three-dimensional anatomical image using fast Tl-weighted spoiled gradient inversion recovery (3D-SPGR) sequence parameters TR/TE= 24 ms/ 6 ms, FA 35°, slice thickness 0.9 mm, FOV=240 mm X 240 mm, matrix=256 X 256; fMRI scanning sequence using T2*-EPI-GRE sequence parameters:TR /TE=2000 ms/30 ms, FA 90°, slice thickness 4 mm, spacing 1 mm, FOV=240 mm X 240 mm, matrix=64 X 64, scan time was 6 min.Data were processed using Statistical Parametric Mapping software (SPM8) pretreatment on the functional data; further developed by Beijing Normal brain function data processing software (Resting-State fMRI Data Analysis Toolkit, REST) for statistical analysis.ResultsChronic waist and legs and normal control group, patients with chronic low back pain at rest, there are some brain regions following exception: chronic low back pain group, bilateral anterior cingulate, bilateral frontal, right occipital ReHo brain regions such as the value of higher than the control group; chronic low back pain group than in the periaqueductal gray, nucleus, pons, the left posterior parietal lobe, bilateral posterior cingulate and adjacent wedge ago Leaves ReHo value lower than the control group.ConclusionResting patients with chronic low back pain functional activities of multiple brain areas abnormal, bilateral anterior cingulate gyrus, bilateral frontal and right occipital brain regions such as the local consistency increased; in the periaqueductal gray, nucleus, pons, the left posterior parietal lobe, bilateral posterior cingulate and adjacent precuneus local consistency reduced; can be understood as this is not a role or a result of several brain areas, and Cortical and subcortical brain structures result of the role; and this may stimulate the body's adaptability to sustained increase in pain, and reduce the endogenous pain control system activities, also related.