| Objective Many researches have shown that carbamylated erythropoietin (CEPO) has cardioprotective effect. however. whether it has treatment effect on chronic heart failure (CHF) remains uncertain. The objective of our study was to observe the reversion of left ventricular remodeling in rats with CHF.Methods 10 of 90 healthy male wistar rats were randomly selected as control group, the others were received intraperitoneally injection of isoproterenol (ISO) to establish CHF model. After 5 weeks, the survived rats were randomly divided into CHF group and CEPO group. CEPO group were administered intraperitoneally at a dose of CEPO 50 ug/kg for 4 weeks, twice a week. CHF group and control group were received equivalent saline at the same time. After the completion of the CEPO injection, hemodynamic, level of BNP and the ratio of left ventricular weight to body weight (LVW/BW) were measured.Results left ventricular end systolic pressure (LVSP). maximal rate of rise/decline of left ventricular pressure (±dp/dtmax) in CHF group were significantly decreased (P<0.05). whereas in CHF group, left ventricular end diastolic pressure (LVEDP), level of BNP and the ratio of left ventricular weight to body weight (LVW/BW) were higher than control group(P<0.05).Compared with CHF group, LVSP and±dp/dtmax were significantly increased(P<0.05), LVEDP, level of BNP and LVW/BW were significantly decreased (P<0.05) in CEPO group.Conclusions To some extent, CEPO can improve cardiac dysfunction in CHF rats by reducing BNP level and alleviating left ventricular remodeling.
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