Comparisons Of T2DM Between Han And She Chinese Population In Fujian Province

Aims: According to the report of the national-wide epidemiologic study by Yang WY, the prevalence of T2DM soared at an alarm rate, amounting to 9.7%. As an ethnic of China, most of She population were located in the southeast of China and little study was performed in this ethnic people. Thus, we focused on Fujian province to investigate the associations of T2DM between Hans and Shes.Methods:All subjects in this study were unrelated population of Fujian province, including Hans(men 1279, women 1988), Shes (men 2308, women 3077). Physical measurements were performed and clinical biochemistry data was collected. For Shes Genomic DNA was extracted from peripheral blood leukocytes, and genotyping was performed with ABI 7500 system based on Taqman probe technology Data analyses were conducted with Windows SPSS 13 statistical software package (SPSS, Chicago, IL, USA).Results: (1)A total of 1430 population were diagnosed as T2DM, 2940 as pr-diabetes. Subject was divided into 5 groups (20 to<30,30 to<40, 40 to <50, 50 to <60, 60 to<70). The standardized prevalence of T2DM was 7.3% for Hans, and 6.1% for Shes. For females, the standardized incidence rate of diabetes in She people was 5.7%, and 6.6% in Han people. And for males, the prevalence rate was 6.7% in She and 7.7% in Han people. The prevalence of pre-diabetes in She people (17.7%) was a bit higher than Han people (12.35%) for males. And the trend was same to females, 22.7% for She people and 11.56% for Han people. It was suggested that the incidence rate of diabetes and pre-diabetes increased significantly in the category of 40 to < 50 years. (2) After adjusted by age, sex and BMI, logistic analyses revealed that rs391300 TT genotype of SRR were both associated with T2DM (OR=1.465, P<0.001), while rs17584499 GG genotype of PTPRD was associated with T2DM (OR=1.677,P=0.009) .Conclusions: The prevalence of T2DM in Shes was much lower than Hans. And of A allele of rs391300 in SRR and G allele of rs17584499 in PTPRD were both risk alleles for T2DM in She population. G allele of rs391300 in SRR gene carry higher risks in Shes than Hans, while the rs17584499 risk allele T was opposite.