Study Of The Correlation Between Plasma Levels Of Beta2-Microglobulin,hs-CRP,Homocysteine And Coronary Lesions In Patients With Coronary Heart Disease

Objective To observe the correlation between plasma levels of Beta2-microglobulin (β2-MG),high sensitivity C-reactive protein(hs-CRP),homocysteine(HCY) and coronary lesions in patients with coronary heart disease(CHD),and approach the role in the development of coronary atherosclerosis.Methods 107 subjects who underwent conronary angiography and calculated Gensini score were divided into two groups acorrding to their coronary angiographic results,69 cases in the conronary artery stenosis group (CAS) and 38 cases in the control group(CG) which the percent of affection of any branch beyond 50%. CAS group was divided into 25 cases of single-vessel lesions,26 cases of double-vessel lesions and 18 cases of triple-vessel lesions.The Radio-immunity and Chemiluminescence method was applied to measure the plasmaβ2 -MG,CRP and HCY concentration.Plasma triglyceride (TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C) and high density lipoprotein cholesterol(HDL-C)were detected,and BMl were measu- red.Comparing the level ofβ2 -MG,hs-CRP and HCY between CAS and CG and subgroups of the CHD,observing the relation between thelevel ofβ2 -MG,hs-CRP and HCY and the degree of coronary atherosclerosis.Results Comparing to the CG group,the plasma levels ofβ2 -MG,hs-CRP and HCY were significantly higher in the CHD group(P<0.05).The more coronary lesions were,the higher plasma levels ofβ2 -MG,hs-CRP and HCY(P<0.05).Conclusion Elevated levels ofβ2–MG,hs-CRP and HCY appear to be associated with agreater number of diseased arteries and the severity of coronary artery disease.Those markers may be helpful To the risk stratification,diagnosis of CHD.Increased levels of serumβ2–MG in CHD patients probably serves as a novel biomarker for the severity of the coronary stenosis.