Human Cytomegalovirus And Polyomavirus Infections In Renal Transplant Recipients

ObjectiveTo investigate Human Cytomegalovirus(HCMV), Polyomavirus (incluing BK virus, BKV). JC virus, JCV) infections and its influence on graft renal function in kidney transplant recipients.Methods53 kidney transplant recipients who treated at our hospital from 2008.9-2009.3 and 30 health examination persons were enrolled. HCMV was measured by pp65 antigenemia using immunohistochemical method of plasma; BK virus(BKV). JC virus(JCV) load were detected by the nested qualitative polymerase chain reaction assays in urine. The possible JC virus infection factors were analysed by T-test and Binary Logistic Regression. Glomerular filtration rate (GFR) was selected as the index of the graft renal function and the difference of GFR between infected and un-infected patients was compared. ResultsThe rate of HCMV, BKV, JCV infections were 26.42%,7.55%,32.08% in kidney transplant recipients, including 7 patients co-infected with HCMV and JCV (13.2%); however, health examination persons were 0%,6.67% and 6.67%. Compared to JCV un-infected, JCV infected patients involved higher rate of using the triple-drug regimen included mycophenolate mofetil(MMF), prednisone(Pred) and cyclosporine(CsA) (76.5% vs 30.6%), the difference reached the statistical significance(t=9.825, P=0.002). The Binary Logistic Regression revealed that the triple-drug regimen included MMF, Pred and CsA was the independent risk factor of JCV infection. The GFR level of HCMV, BKV, JCV, HCMV+JCV infected and un-infected patients were as 86.84±35.660 ml/min·1.73m2,99.95±29.622 ml/min·1.73m2,86.22±33.680 ml/min·1.73m2,75.82±23.905 ml/min·1.73m2 and 79.80±34.202 ml/min·1.73m2, no difference was observed between them(F=0.455, P=0.768).ConclusionHuman Cytomegalovirus and Polyomavirus, are not uncommon in kidney transplant recipients. Higher rate of JCV infection than BKV may due to the triple-drug regimen using included MMF, Pred and CsA. Although, neither HCMV nor Polyomavirus infections appeared to influence graft renal function post-transplantation.