The Epidemiological Survey Of Non-alcoholic Fatty Liver Disease In Health Checkup People In Chaoshan Region

0bjectiveTo investigate the prevalence and risk factors of Non-alcoholic fatty liver disease (NAFLD) in health clinical examination population in Chaoshan region, and to explore the relationship of alanine aminotransferase and metabolic syndrome and its components, in order to provide more theory for Non-alcoholic fatty liver disease's treament.MethodThe survey was conducted among 1221 adults from October 2010 to January 2011 in medical examination center in the Fisrt Affiliated Hospital of Medical College of Shantou University. The participants had patient history, clinical examination, anthropometry, laboratory tests and routine liver ultrasonography. Use case-control study, patients were divided into two groups(NAFLD and non-NAFLD) and compared their demographic characteristics, biochemical, metabolic syndrome and its components. Then, the patients with NAFLD were divided into two groups including elevated serum ALT and normal serum ALT. Compared the two groups in demographic characteristics, biochemical, metabolic syndrome and its components. Using binary logistic regression analysis risk factors of non-alcoholic fatty liver patients with high ALT levels.Result1. Of 1221 adults took part in the survey, 854 were males and 367 were females. The mean age of the participants was 46.40±14.67 years and ranged from 18~95 years. The age-sex-adjuste prevaence of NAFLD in all participants was 29.1%. The age-adjusted prevalence of NAFLD in men (33.9%) was significantly higher than that in women (18%)(P=0.001). The prevalence of NAFLD was increased with aging in males and in females(tendency,P<0.001). 2.The body mass index(BMI), waist circumference(WC), waist hip ratio(WHR), blood pressure, fasting blood glucose level(FBG), triglyceride(TG), total cholesterol(TC), low-density lipoprotein cholesterol(LDL-C), uric acid(UA), alanine aminotransferase level(ALT), and the incidence of obesity, hyperuricemia, hypertension, dyslipidemia, abnormal hepatic function in NAFLD group were significantly higher than those in the group without fatty liver(all P<0.001), but the high-density lipoprotein cholesterol(HDL-C) level was lower in NAFLD group (P<0.05). Multivariate logistic regression analysis demonstrated that age(OR:1.025, 95%CI 1.014-1.035,P<0.001), WC(OR:1.067, 95%CI1.044-1.092, P<0.001), BMI(OR:1.263, 95%CI1.185-1.346, P<0.001), and elevated triglyceride(OR:1.460, 95%CI1.257-1.694, P<0.001) as risk factors for NAFLD. 3. High prevalence of obese and hyperlipidemia in NAFLD elevated serum ALT group (P<0.05). Logistic regression analysis demonstrated age(OR:0.967, 95%CI 0.949- 0.986, P=0.001) was protectant factors for non-alcoholic fatty liver disease with high ALT levels,while BMI(OR:1.115, 95%CI1.015-1.225, P<0.05) and TG (OR:1.250, 95%CI 1.032- 1.153, P<0.05) were risk factors for non-alcoholic fatty liver disease with high ALT levels.ConclusionNAFLD prevalence in health clinical examination population in Chaoshan region was very high. The development of NAFLD was closely associated with elevated ALT and many metabolic disorders;age, obese and elevated triglyceride levcel were risk factors for NAFLD. Among the metabolic components, BMI and triglyceride levcel have clsose reationp with NAFLD with elevated ALT levels.