Study On The Autonomic Nervous Function State Of Deficiency-Excess Syndromes In TCM Of Coronary Heart Disease

Background:Heart Rate Variability (HRV) refers to tiny fluctuation between continuous heartbeat. HRV reflects the regulation of autonomic nervous system on the cardiovascular activities. HRV analysis of health person and patients can help us understand the function of autonomic nervous system activity, which can reveal characteristics of autonomic nervous function in different diseases and different states. The study showed that there was close correlation between HRV and Traditional Chinese Medicine(TCM) syndromes.Objective:To analyze HRV of patients of different TCM syndromes with coronary heart disease(CHD) and reveal the relationship between HRV and TCM syndromes, in order to provide new way for the study of TCM syndromes.Methods:In total,211 patients were enrolled in this study. All General clinical information and TCM diagnosis information of patients were collected. Then they were encouraged to wear holter analyzer in order to collect 24 hours ECG information. According to TCM diagnosis information,211 cases were divided into three groups including excess-syndrome, deficiency-syndrome and coexistent deficiency and excess syndromes. Frequency domain and time domain information were directly gained by holter analysis software, while the nonlinear information analyzed by Professionals. The HRV indexes of three groups were compared.Results:1.All time domain indexes including SDNN, SDNNindex, RMSSD, PNN50 had statistically significant difference among the TCM syndrome groups, and the order was the excess-syndrome group>coexistent deficiency and excess group>the deficiency syndrome group.2. Frequency domain indexes including TP, LF, HF, VLF had statistically significant difference among groups, and the order was the same as the time domain indexes, while LF/HF had no statistical significance among groups.3. Nonlinear parameters, complexity at noon had significant difference among groups, and the order was the same as time domain. correlation dimension, Approximate entropy (ApEn) both at noon and midnight had no difference among groups. 4. We observe 54 cases who had nonlinear scatter plots, excess-syndrome group had 33.33%(6 of 18) scatter plots as baseball bat,and the deficiency group only had 6.67%(1 of 15).The long axis, wide axis, wide axis/long axis (SD1/SD2) and the area of scatter plots had no differences between groups. In the time domain indexes and the frequency domain indexes,only SDNN and HF had difference among groups,and the excess-syndrome>the deficiency syndrome.Conclusion:HRV reflected the state of human autonomic nervous system normal or not, and different HRV indexes reflect different states of autonomic nervous system; Time domain and frequency domain indexes of patients with Coronary heart diseases in the excess syndrome group were all in the normal range, there was no obvious damage on autonomic nervous system in this group, and the parasympathetic and sympathetic were in equilibrium; HRV indexes of deficiency syndrome group were below normal range, There was obvious decrease on autonomic nervous function, and the parasympathetic and sympathetic were in low-level equilibrium.