Beidan Yifei On Angiogenesis In Rats With Idiopathic Pulmonary Fibrosis Effects Of ET-1 And VEGF

Objective: Beidan Yifei experimental study on angiogenesis of rats with pulmonary fibrosis, prescription can cut through by plasma ET-1 concentration and pulmonary VEGF content in tissue homogenate, weakened abnormal angiogenesis and thus reduce lung fibrosis.Methods: 54 random in rats were divided into five groups, that is, blank-control group, model control group, Chinese medicines in the treatment group (low and high dose group) and drug-positive groups (high-dose group), each group of 12. By to large rats tracheal within injection Bole mold pigment (BLM) established lung fiber of model, made touch success Hou model group, and blank controlled group are given saline 10mg/kg.d irrigation gastric, daily once; positive drug group given strong of pine water solution 10ml/kg.d irrigation gastric, daily once; Chinese medicine low dose group given Bedan Yi Lung water fried liquid 10ml/kg.d irrigation gastric, Chinese medicine high dose group given Beidan Yi Lung water fried liquid 40ml/kg.d irrigation gastric, and 7th days, and 21st days two time points respectively based.Observation Beidan Yi Lung party on Lung fiber of large rats vascular generated in the of endothelial pigment 1 (ET-1), and vascular endothelial growth factor (VEGF) of effect, while by on Lung Organization General observation, HE and Masson dyeing light mirror lung organization pathological morphology half quantitative analysis, observation large rats pathological learn change, determine alveolar inflammatory and lung fiber of degree, on Lung organization slice for SP immune group of dyeing, observation lung organization vascular generated State for vascular count and the calculation vascular density.Results: 1. Beidan tonifying the lung can reduce alveolar inflammation and pulmonary fibrosis, Beidan Yifei curative effect of high dose group was superior to Beidan Yifei low dose group and prednisone Group; 2. prescription of traditional Chinese medicine can cut through by plasma ET-1 concentration and pulmonary VEGF content in tissue homogenate, weakened abnormal angiogenesis and thus reduce lung fibrosis.Conclusion: Beidan Yifei adjustable excessive angiogenesis, fundamentally prevent pulmonary fibrosis development, the overall effect is better than high-dose control group, provides the scientific rationale for further application.