| Objective 1.Understanding of hospital diabetes (DM) patients with peripheral neuropathy (DPN) prevalence.2.Analysis of risk factors for DPN.3.Analysis of DM-related microvascular complications and whether DPN.4. Learn ankle-brachial index (ABI) and the relationship between the DPN and the ABI and lower extremity arterial disease in DPN (PAD) in the diagnosis.Methods Select Ningxia Medical University Hospital in April 2009–November 2009 in endocrinology during the month of hospital treatment of type 2 diabetes (T2DM) patients for the study of 192 cases.Based on sensory nerve conduction velocity (SCV) or / and motor nerve conduction velocity (MCV) were divided into abnormal or type 2 diabetes with peripheral neuropathy group (DPN group) of 124 cases with peripheral neuropathy and non-group (no DPN group) 68 cases. General information on the two groups were collected and the laboratory parameters. DPN will affect the relationship between factors and univariate analysis, the measured data to that between the two groups using t test for comparison between the sample rate of x2 test. In order to control the mutual interference between elements, Genju single factor analysis, statistical significance and the card Xuanze You square value Jiexian closely significant risk factor into the Ren Logistic a regression model Feitiao Jian many factors to reflect the risk factors associated with DPN. And different cut points to ABI group, on the incidence of DPN in each group were x2 test.Results1. Study of 192 cases 100 cases male, female 92 cases, aged 33 to 78 years, mean age 57.85 ±11.252, Duration <5 years 40 cases, 152 patients≥5 years duration, the average duration of 9.58±7.065 years. According to neural electrophysiological examinations, DPN group of 124 cases, the prevalence was 64.58% (124/192), DPN 72 male patients, 72% (72/100), female DPN 52 cases, accounting for 56.52% (52/92) in men than women.2. DNP group and no single factor DPN group compared, DPN group's age, duration, fasting blood glucose (FBG), postprandial 2h plasma glucose (2hBPG), glycosylated hemoglobin (HbA1c), triglycerides (TG), total cholesterol (TC), blood urea nitrogen (BUN) and urinary microalbuminuria protein (MA) were increased, the differences were statistically significant (P<0.05); High-density lipoprotein cholesterol (HDL-C), total bilirubin (TBIL), direct bilirubin (DBIL) and indirect bilirubin (NDBIL) DPN group were lower than those without DPN group; The BMI, low-density lipoprotein cholesterol (LDL-C) and combined systolic and diastolic blood pressure increased between the two groups showed no statistical significance; Combination of DPN and the rate of coronary heart disease than those without DPN group, the difference was statistically significant. All subjects were divided according to duration of disease <5 years, 5 to 9 years, 10 to 19 years,≥20 years, 4 groups, statistical analysis showed that duration≥5 years after the DPN in each group were significantly increased several times over, duration≥20 years, DPN 100% occurred. HbA1c>6.5% group had higher incidence of DPN HbA1c≤6.5% group. DPN ABI group had significantly lower than DPN group.3. The study to ABI≤0.9 and ABI<0.9 were divided into two groups, ABI≤0.9 group, the incidence of DPN was 90%, ABI<0.9 group, the incidence of DPN was 57.89%, by the X2 test, P<0.01, DPN morbidity between the two groups was statistically significant.4. DPN groups with and without diabetic nephropathy (DN) and diabetic retinopathy (DR) compared the incidence of statistical significance.5. With DPN as the dependent variable, a single-factor analysis of the difference between indicators as independent variables, multivariate Logistic regression analysis showed that duration, HbA1C, TG, DN, DR and PAD (ABI≤0.9) as risk factors for DPN, HDL-C and NDBIL a protective factor for the DPN.Conclusion1. The study by electromyogram diagnosis DPN, the incidence rate of 64.58%. Tip: As a diabetes specialist, to improve early diagnosis of DM in patients with DPN awareness for early prevention and treatment.2. In this study, multivariate Logistic regression analysis showed that duration, HbA1c, TG, DN, DR and PAD (ABI≤0.9) as risk factors for DPN, HDL-C and NDBIL a protective factor for the DPN.3. Reduced ankle-brachial index (ABI≤0.9) in the diagnosis of diabetic peripheral neuropathy 90% reliability, it is a sensitive clinical indicator of early screening; peripheral neuropathy and vascular disease related.4. Nerve conduction velocity test is early detection and effective means of peripheral neuropathy. Screening phase of the inspection will be ankle-brachial index as a routine examination. |
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