| Objective To investigate the impact factors on recurrent upper respiratory tract infections(RRTIs) and change of T lymphocytes,NK cell in children aged 3 to 6 years in Shanxi. For enhancing the quality of children life,avoiding unreasonable therapy in order to explore new method for taking prevention measures.Methods 230 Children aged 3 to 6 years were collected with strict criterion choice and abandoned. The case group had 118 samples, the control group had 112 samples. case-control study was used. one self-administered questionnaire was used to know children'general information, nutrition, the way parents breed children and family environment. The expression of CD3, CD4, CD8 on T cells; CD16 CD56 on NK cells from peripheral blood was evaluated by a flow cytometry method. SPSS13.0 software were used for data analyses:the equilibrium test compared by t-test andχ2 analysis; the impact factors on RRTIs were analyzed by the Logistic regression. The subset of T lymphocytes compared by Wilcoxon rank sum test of two independent samples, NK cell was compared by t'-test.Results1,There were no significant difference in sex(χ2=1.584,P=0.208), age(t=1.650, P=0.100), weight(t=0.341,P=0.733), height(t=0.124,P=0.902) between case group and control group(P>0.05). which indicated that the sample can represent the population.2,The impact factors on RRTIs:①The risk factors:1 to 3 times intake of vegetables every week (OR=5.195,95%CI(1.193,22.624)), kindergartens (OR=5.642,95%CI (1.149,27.702)),RRTIs disease history (OR=8.129,95%CI (2.725,24.256)), and less than outdoor exercise of 2 hours (OR=5.291,95%CI (1.576,17.763))②The protective factors:the level of father education (OR=0.134,95%CI(0.034,0.527)), taking 4 to 6 times fruits every week (OR=0.231,95%CI(0.069,0.775)), lower 3 frequencies using of antibiotics in one year (OR=0.028,95%CI(0.003,0.303))3,The subset of T lymphocytes compared by Wilcoxon rank sum test of two independent samples, we concluded that there were no statistically significant difference for all comparisons. CD3+(Z=-1.588, P=0.112), CD4+(Z=-0.541, P=0.588), CD8+(Z=-0.733, P=0.463), CD4+/CD8+(Z=-0.315, P=0.753).4,There were statistically significant difference in NK cell between two groups. (t'=2.779,P=0.006,95%CI(0.674,4.003))Conclusions 1,From the conclude of the impact factors:①Keeping intake of vegetables,fruits, meat.②Reasonably arrange time of outdoor exercise everyday may decrease the frequencies ofRRTIs.③It is positive affect for recurrent respiratory tract infections to the higher level of parents'education, especially father.④Kindergartens should enhance the work of health care. Do examine in morning,noon and evening. Finding the disease'children should be isolation in time. To decrease or avoid the cross-infection.⑤Respiratory tract infection in children should be therapied in time, and reasonably use the drug, to avoid abusing antibiotic.2,From the conclude of the lymphocytes:①For children on RRTIs, T lymphocytes were not change. In prevention, we should reasonable use immunomodulation, to avoid generating a great economic impact.②In the clinic, flow cytometric analysis of the subset of NK cell is a useful means for RRTIs. |
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