Curcumin Combined With Indomethacin Treatment Of Senile Dementia Of The Experimental Study

Backgroud Alzheimer's disease (Alzheimer's Disease, AD), one of the common diseases of the nervous system. AD is a multi-hair in the elderly for cognitive impairment and memory impairment mainly of the central nervous system degenerative diseases,AD has become, following cardiovascular diseases, cancer and stroke, after the threat of disease, the fourth largest health of older people.Currently the world has entered an aging society, China is no exception.Inflammatory response and oxidative stress is a physiological mechanism of Alzheimer's disease pathology in two important aspects of.indomethacin and curcumin are anti-inflammatory antioxidant。Indomethacin by inhibiting glial cells and neurons produce substances prostaglandins (PGs), to reduce inflammation-induced cascade of positive feedback likely to reduce the quality of the generated peroxide.Curcumin through the Janus kinase-STAT signaling pathway to suppress the inflammatory response, Curcumin can reduce the tissue neutrophil infiltration, Curcumin supports the immune system to clear amyloid protein, Curcumin can prevent the aggregation of Aβ, and the end of the structural changes caused by Aβ, Curcumin can inhibit the xanthine dehydrogenase to xanthine oxidase conversion, reducing the generation of free radicals.Purpose To clear the efficacy of curcumin treatment of AD, Observation of curcumin with indomethacin treatment differences in the efficacy of AD, Explore the possibility of combination therapy, from the pathophysiological mechanism of curcumin and indomethacin on NOS and ACHE in AD, and the effects of curcumin.Further clarify the curcumin with the possibility of indomethacin by means of AchE and NOS play a role in treatment of AD.Methods The whole animal experiment. (1) Preparation of rat model of AD. (2)The rats were randomly grouped for drug intervention, divided into model group, normal control group, indomethacin group, the curcumin group, curcumin combined with indomethacin treatment group. (3)The maze experiment testing behavioral. (4) Chemical reagent measuring AchE,NO and NOS.Results Learning and memory in model group decreased liquidity for the swim to safety sets the longest and most frequent errors with the healthy control group and drug difference between groups was significant (P<0.05), and along with the training, the number of differences become more pronounced. The best result is in the combination group, followed by the curcumin group, indole group of somewhat less.Indicators ACHE by analysis of variance, F= 27.68, P<0.001, indicators of CHE, F= 20.25, P <0.001, indicators of NO by analysis of variance, F= 39.642, P<0.001, indicators of NOS,F= 88.411, P<0.001, the difference was statistical significance. Further use of the above indicators LSD pairwise comparison methods to compare results to the combination group the best, the curcumin group center, indole group of poor.Conclusion (1)In rat hippocampus using an injection ofβ-amyloid protein (Aβ25-35) can cause AD model. (2)Effect of curcumin treatment of AD more effective than indomethacin, together with indomethacin can increase the efficacy. (3) Curcumin can reduce the AD brains of rats NOS content and the content of AchE. (4) Curcumin and indomethacin can be NOS, AchE way to play a therapeutic effect.