Effect Of Liver X Receptor Agonist On Aorta Structure,blood Vessel Activity In Atherosclerosis Mice

Background: Lipid metabolism and inflammatory reaction parallel the severity of atherosclerosis vasculopathy. Though liver X receptors agonist has a critical role in the progression of atherosclerosis cardiovascular disease, no link has been established between arterial injuries induced by atherosclerosis with the level of activity of the arteriae aorta. We hypothesized that atherosclerosis contributes to endothelial dysfunction and alterations of structure and function in the arteriae aorta.Furthermore, liver X receptors agonist would enhance activities that are associated with arteriae aorta vasculopathy in atherosclerosis(AS). Methods: To test the hypothesis, atherosclerosis sample was apolipoprotein E Deficient Mice[ApoE(- / - ) ], which treated with liver X receptors agonist. [ApoE(- / - ) ]mice treated with liver X receptors agonist and individual control mice were measured by immunohistochemical localization, Western blot analysis . The vasomotorial function was evaluated and expression of ABCA1 levels on the arteriae aorta . The ultrastructural changes were observed by transmission electron microscope.Results: The data demonstrates that levels of cholesterol and low-density lipoprotein cholesterol (LDL-C) in AS+LXR group were significantly lower than those in AS group (P<0.05). LXR agonist could inhibit degeneration and necrosis of endothelium and significantly reverse the development of atherosclerotic lesions than those in AS group .Expression of ABCA1 in the artery wall were elevated in AS+LXR group compared with AS group (p<0.05). The KCl/noradrenaline-induced vasoconstrictive function and acetylcholine-induced vasodilative function were decreased in the isolated arteries from AS mice (p<0.05). Treatment with liver X receptors agonist improved the structure and function of the arteriae aorta.Conclusions: Our study provides evidence liver X receptors agonist may induce vascular injury. Liver X receptors agonist may be effective for the treatment of atherosclerosis vascular disease.