Research Analysis Of Professor Shao Zhaodi's Experiences On Treating Refractory Nephrotic Syndrome

This subject relies on the"11th Five-Year Plan" National Science and Technology Support Program——"Exploration on transfer the experience and academic thought of the aged famous doctor of TCM (Traditional Chinese Medicine)". Through the clinical practice with Professor Shao, the author collects and organizes her clinical material of diagnosing and treating in order to research Professor Shao's clinical experience and academic thought toward the treatment of Refractory Nephrotic Syndrome (RNS), offer clinical references for treatment of RNS with TCM, and establish the theoretical foundation for inheriting the famous old doctor's experience in combination with this research. There is no record of " refractory Nephrotic Syndrome" in TCM, but it could be classified as "edema", "Shui Qi" and so on, based on its clinical manifestations. Professor Shao considers the internal and external factors can disorder the function of lung, spleen, kidney and then cause the disease. If it attacks repeatedly, the type of TCM syndrome of the disease transforms to deficiency of vitality and excess in superficiality eventually, and combination of excess and deficiency. Spleen-Kidney deficiency is the key of the Pathogenesis.Professor Shao divides "Refractory Nephrotic Syndrome(RNS)" into Ben-Zheng and Biao-Zheng. Both of them include four types, so the treatments are:WenShenJianPi, YiShenBuFei, ZiBuGanShen, YiQiYangYin, WenShenHuaQiLiShui, QingRenLiShui, XuanFeiJianPiLiShui, HuoXueHuaYuLiShui separately.Based on the spleen and kidney, Professor Shao treats it with warming and nourishing. But according to specific cases and different phases of using glucocorticoid, the treatment is not just warming and nourishing. Paying attention to the change of using glucocorticoid and Qi-Blood-Yin-Yang, Professor Shao dialectically uses JiaWeiShenQiTang, ShiPiSan, LingGuiZhuGanTang, WuLingSan, ZhiBaiDiHuangTang, YiGuanJian, ShenQiDiHuangTang, LiuWeiDiHuangTang, ShuiLuErXianDan, etc.While establishing at the deficiency in the basis of the disease, Professor Shao also emphasizes that exogenous, moisture, damp-heat, stagnation of blood play an important role in the evolution of this disease. They are not only prolonging and aggravating the disease, but also a key factor of this disease that is difficult to cure. Professor Shao stresses identification of deficiency and excess and gives consideration to both Biao and Ben.Professor Shao uses medicine exquisitely in order to acquire distinct efficacy. For instance, she is fond of using Atractylodes, Astragalus, Rosa laevigata, Euryale ferox, Salvia; using Radix Rehmanniae usually instead of Rehmannia; paying attention to the bitter-cold of Paeonol; not using Licorice to reinforcing spleen and reconciling the effects of the herbs.Infection is a major inevitable relapse and aggravating factor. Whether at the beginning of infection or the remission of the disease, Professor Shao warms to prevent infection. Clinical practice has shown that the disease is easy to recover by preventing and controlling infection actively.Though the treatment of RNS is difficult, Professor Shao is a expert in treating with Integrated Chinese and Western Medicine. If glucocorticoid therapy is ineffective, Professor Shao uses separately the method of syndrome differentiation in TCM; On the condition that the glucocorticoid therapy is effective, using TCM dialectically not only reduces the toxic and side-effects of western medicine, but also significantly improves the curative effect, lowers the rate of the disease recurrence, and prolongs remission, which can better reflect the treatment advantage of the disease with TCM.