Clinical Features And Survival Analysis Of Molecular Subtyping Of Uygur Breast Cancer

Objective To study the clinical pathological features and prognostic status of molecular subtyping of breast cancer in 153 cases of Uygur patients. Methods The clinical data of 153 patients with Uygur breast cancer, admitted to Xinjiang Medical University Cancer Institute & Hospital from Janury 2004 to Janury 2005, were collected and analyzed retrospectively. Molecular subtypes, based on immunohistochemistry staining results, were categorized as follows: Luminal A [ER(+) or PR(+)/HER-2(-)], Luminal B [ER(+) or PR(+)/HER-2 (+)], HER-2(+) subtype [ER(-), PR(-)/HER-2 (+)], and Basal-like subtype[ER(-), PR(-)/HER-2(-)].. Survival rate was calculated by applying Kaplan-Meier. Results Among the 153 cases, 89 cases (58.2%) were Luminal A subtype, 11(7.2%) were Luminal B subtype, 19(12.4%) were HER-2(+) subtype, and 34(22.2%) were Basal-like subtype. There are not significantly different with repect to age, menopausal status, family history, tumor size, node status, TNM stage, and histological type in different subtypes. Complete follow up data were obtained in 153 cases , the median follow-up time was 45 months, Distant metastatic rates were not significantly different between HER-2(+)subtype and Basal-like subtype (P<0.050). Kaplan-Meier analysis showed DFS and OS of 4 subtypes were different statistically, Log-Rank test showed there was higher over survival (OS) in Luminal A subtype than those in HER-2(+) subtype and Basal-like subtype, and higher disease free surivival (DFS) in Luminal A subtype than that in Basal-like subtype, (P<0.050). Conclusions Molecular subtyping of Uygur breast cancer may provide the important basis for individualized treatment of uygur breast cancer. and could be of clinical significance for survival and prognosis of Uygur breast cancer patients.