| Objective:To study clinical features of 77 congenital syphilis patients.Methods:Retrospective analysis was done in the group of 77 cases in children who were diagnosed as of congenital syphilis in children's hospital of Chongqing medical university from February 2006 to November 2009. Respectively neonatal period and non-neonatal period, whether or not combine with other TORCH infection in sub-group analysis of the main clinical manifestations, multi-system damage and characteristics in respect of laboratory, the results of follow-up TRUST.Reasults:1.77 cases of CS in children the incidence of multiple organ damage from high to low are: respiratory system, digestive system, skin, blood system., and AST transaminase elevation to the digestive system in the main.2.Laboratory examination, 77 cases of congenital syphilis in children with positive rate of abnormal laboratory tests are: coagulation 88.9% (16/18), long bone X films 76.7% (46/60), myocardial enzymes 76.3% (29/38), renal 16.4% (9/55).3.Neonatal period and the non-neonatal period in the incidence of the rash, nasal resistance, edema, dyspnea or cyanosis, spits up choking or coughing, suspected diagnosis, increased of liver and spleen, anemia, intracranial hemorrhage was significant difference (P < 0.05), while abdominal distention, leukocytosis, thrombocytopenia, elevated aminotransferases, bilirubin increased, low-protein, chest radiograph, abnormal urine was no significant difference (P > 0.05).4.There were 37 cases of children with CS complicated with other TORCH infections, pure CS group and combined with other TORCH group the incidence of increased liver and spleen, anemia, thrombocytopenia, elevated transaminase, hypoalbuminemia and positive chest X-ray are significant difference (P < 0.05), and combined with other TORCH group have a higher incidence, but premature birth, low birth weight, intracranial hemorrhage, the incidence of hearing impairment was no significant difference (P > 0.05).5.77 cases of CS, 23 cases were followed up a TRUST, which was negative in 19 cases, 4 cases were followed up until June when the decline in titer only. 19 cases of CS in the month when the TRUST 1,2,3,6,12,13 negative rates were 26.3% (5/19), 36.8% (7/19), 57.9% (11/19), 78.9% (15/19), 94.7% (18/19), 100% (19/19)Conclusion:1.77 cases of CS in children with respiratory system, digestive system, the increased aminotransferases (AST elevated more obvious), and bilirubin increased, rash, blood system, anemia, liver and spleen increased, and hypoalbuminemia as the major systems damage to the performance. CS is a whole body systemic infectious diseases, coagulation dysfunction, bone damage, myocardial injury have a high incidence, and Long bone X-ray examination may provide important diagnostic evidence. it is suggested for children with improved multi-system-related CS examination.2.CS in the neonatal period performance was not typical, and there are differences with the non-neonatal period. Neonatal period with suspected medical diagnosis or to seek treatment for asymptomatic CS was significantly higher than non-neonatal period. In non-neonatal period the incidence of skin rash, nasal resistance, edema, increased liver, increased spleen and anemia are higher, is more typical than the neonatal period. Therefore, neonatal screening for CS do is important.3.CS easily combined with other TORCH infection, combined with other TORCH infection of CS in the respiratory system, digestive system, blood system, the incidence of injury was higher than the pure CS, caused by the liver and spleen enlargement, anemia, thrombocytopenia, elevated aminotransferases hypoproteinemia and respiratory damage were significantly increased, transaminases increased more significantly, liver damage increased, but the incidence of congenital heart disease did not significantly increase.4.CS patients were followed up for TRUST, and TRUST more in the negative within 6-12 months... |
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