The Study Of Relationship Between Gammaglutamyltransferase And Arterial Pulse Wave Velocity,Endothelial Function

Objective: To investigate the relationship between gamma-glutamyltransferase (γ-GT or GGT)and brachial-ankle wave velocity (ba-PWV),flow-mediated dilatation (FMD) of brachial arteryin the patients suffered from CHD.Methods: Brachial-ankle wave velocity (ba-PWV) was measured by VP-1000 automatedanalyzer. Gamma-glutamyltransferase was measured in the morning. Flow-mediated dilation(FMD) of brachial artery was measured by high resolution ultralsound assessment of the brachialartery diameter.Results: 91 patients with CHD and 30 non-CHD were recruited in the study:Both GGT andba-PWV was higher in CHD as compared to the non-CHD group (64.86±19.58 vs 17.63±6.76,P<0.001; 13.17±2.57 vs 8.79±1.89; P<0.001). FMD was lower in CHD as compared to thenon-CHD group (7.27±1.46 vs 12.59±2.57; P<0.001). Univariate analysis demonstrated thatthere was a significant relationship between GGT and ba-PWV,FMD (P<0.001). In all recruitedsubjects,multivariate stepwise regression analysis demonstrated that GGT was significant andindependent factors for ba-PWV and FMD.Conclusion: Compared with patients without CHD,there were higher GGT in patients withCHD. GGT might have some value for CHD diagnosis. GGT was positively correlated withba-PWV and GGT might be involved to the pathogenesis of arteriosclerosis. FMD wasnegatively correlated with GGT. Perhaps the underline mechanism between GGT andarteriosclerosis is the vascular endothelial dysfunction.