| 1.To explore the correlation between TCM syndromes of coronary heart disease (CHD) and lesions degree of coronary artery.2.By dual-source CT (DSCT) and selective coronary angiography (SCAG) clinical study to explore the diagnostic value of DSCT for evaluation of coronary artery disease and find the clinical value and feasibility of macroscopic index in different TCM syndrome types of CHD.3.To explore the correlation among IL-6,hs-CRP,ox-LDL levels,TCM syndromes of CHD and lesions degree of coronary artery.4. To explore the correlation among pulse pressure(PP),TCM syndrome differentiation and lesions degree of coronary artery in CHD.All 131 cases who were diagnosed as Chest Stuffiness and Pains received SCAG and DSCT examination,and then hs-CRP,IL-6,ox-LDL and blood lipid indexes were measured by ELISA. The 131 patients were divided into the CHD group(91 cases)and the control group(40 cases) by SCAG,then analyzed the correlation of DSCT,IL-6,hs-CRP,ox-LDL levels, pulse pressure(PP) and TCM syndromes of CHD and lesions degree of coronary artery.1.Lesion degree of coronary artery was more severe (more than two artery lesions, severe coronary stenosis and total occlusion of coronary artery, Gensini score> 30 points),more common in Heart blood stasis and Phlegm turbid retention syndrome;mild disease (single artery lesions, mild coronary stenosis, Gensini score<30 points) in patients with focus on type of heart qi deficiency,heart kidney Yang Deficiency, and heart kidney Ying Deficiency,in which mainly heart qi deficiency syndrome.2.DSCT for the assessment of lesion degree of coronary artery is similar in severity of coronary lesions with high specificity and sensitivity with the SCAG, especially for severe stenosis of the judge.3. The levels of IL-6 and hs-CRP in CHD groups were obviously higher than the normal control group (P<0.05).The levels of IL-6 and hs-CRP of the blood-stagnation type, the phlegm-turbid type, cold-coagulation type were significantly higher than the other syndromes (P <0.05), but there was no statistical significance in this three types (P>0.05). Besides, there was also no statistical significance in the other three types (P>0.05);The levels of IL-6 were very obviously significant among varied coronary lesions groups (P<0.01). The level in triple-artery lesion group is highest, the double-artery lesion group is higher; The level of hs-CRP in triple-artery lesion group was significantly higher than the single-artery lesion group (P<0.05).Respectively compare the level of hs-CRP of double-artery lesion group to single-artery lesion group and triple-artery lesion group, there was no statistical significance (P >0.05); The levels of IL-6 and hs-CRP of the total occlusion group were significantly higher than the moderate stenosis (P<0.01) and severe stenosis groups (P<0.05), but there were not significantly different between moderate stenosis and severe stenosis group (P>0.05)4. The levels of ox-LDL in CHD groups were obviously higher than the normal control group (P<0.05);The level of ox-LDL was very obviously significant among varied coronary lesions groups (P<0.01);The level in triple-artery lesion group is highest, the double-artery lesion group is higher; The levels of of the total occlusion group were significantly higher than the moderate stenosis and severe stenosis groups (P<0.05), but there were not significantly different between moderate stenosis and severe stenosis group (P>0.05). The levels of ox-LDL of the blood-stagnation type,the phlegm-turbid type,cold-coagulation type were significantly higher than the other syndromes (P<0.05), but there were no statistical significances in this three types (P>0.05). Besides, there were also no statistical significances in the other three types (P>0.05).5.There were significant differences between PP≤40mmHg group and PP40-60mmHg group (P<0.05) and PP>60mmHg group (P<0.01) in degree of coronary artery lesions and different TCM syndromes of coronary heart disease;There was no significant difference between PP 40-60mmHg group and the PP>60mmHg group in the severity of coronary lesions and different TCM syndromes of coronary heart disease (P>0.05).1. DSCT could be used to evaluate coronary artery lesions with relatively high sensitivity,specificity and accuracy.especially to severe narrowing.lt could be a reliable noninvasive and objective index for TCM syndrome differentiation in CHD. 2.The levels of hs-CRP,IL-6,ox-LDL and Pulse pressure were correlated with TCM syndromes of CHD and severity of coronary lesions.They may be the objective indexes for TCM syndrome differentiation in CHD,and be the objectification basis in estimating the severity of coronary lesions. |
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