Study On The Traditional Chinese Medicine Types Of Syndrome Of Chronic Hepatitis B With HBeAg Negative

Objective:The aim of the study was to explore the relationships of symptoms and syndrome differentiation typing.By measuring liver function, HBV-DNA quantitation and hepatic fibrosis, explore its differences in order to direct clinic treatment, through which we can find the theory basis of the diagnosis and differentiation of syndrome differentiation typing in patients with chronic hepatitis B with HBeAg negative.It can make clinic treatment more individual and efficiency.Methods:120 patients with chronic hepatitis B with HBeAg negative were divided into five groups based on syndrome differentiation typing.We investigated the level of liver function, HBV-DNA quantitation and hepatic fibrosis, in order to explore the relations between syndrome differentiation and these markers, and analyze their correlations by statistics test.Results:In this study,120 cases collected HBeAg negative chronic hepatitis B patients, 75 cases of which are liver depression and spleen deficiency, accounting for 62.5%; The rest cases are as follow:Heat resistance permits in 27 cases,22.5%; 8 cases of liver and kidney negative evidence, accounting for 6.7%; blood stasis syndrome in 7 cases,5.8%; 3 cases of spleen deficiency syndrome, accounting for 2.5%.HBeAg negative chronic hepatitis B patients in the liver function indicators, the comparison between each syndromes, AST, GLB, STB was no significant difference (P>0.05); ALT liver depression and spleen deficiency in and heat in the resistance card, the difference was statistically significant (P= 0.006), liver stagnation and spleen deficiency syndrome and Kidney Yin Deficiency, the difference was statistically significant (P=0.008), stagnation and spleen deficiency syndrome and spleen deficiency card, the difference was statistically significant (P=0.047); in GGT in the stagnation and spleen deficiency syndrome and blood stasis syndrome, the difference was statistically significant (P= 0.01).In HBeAg-negative chronic hepatitis B patients in the three indicators of hepatic fibrosis, the comparison between two syndromes, HA in the liver stagnation, and damp heat resistance spleen deficiency syndrome, the difference was statistically significant (P=0.012), Stagnation and spleen deficiency syndrome and blood stasis syndrome, the difference was statistically significant (P=0.003); blood stasis syndrome with spleen deficiency syndrome, the difference was statistically significant (P=0.02); PIIIP in liver Yu-deficiency syndrome and blood stasis syndrome, the difference was statistically significant (P=0.008), blood stasis syndrome and Blood, the difference was statistically significant (P=0.032), blood stasis Card and spleen deficiency syndrome, the difference was statistically significant (P= 0.022); IV-C in the liver stagnation and spleen deficiency blood stasis syndrome, the difference was statistically significant (P=0.000), blood stasis syndrome and heat in the resistance card, the difference was statistically significant (P=0.005), blood stasis syndrome and liver kidney yin, the difference was statistically significant (P=0.012), blood stasis syndrome with spleen deficiency syndrome, the difference was statistically significant (P= 0.025).The level of viral replication and liver fibrosis and liver function relationship of three:the indicators of liver function, HBV-DNA replication moderate group (105 to 106 copies/ml) and HBV-DNA replication mild group (103 to 104 copies/ml) in the GLB value comparison, the difference was statistically significant, suggesting that GLB and HBV-DNA replication moderate degree of correlation.Other indicators of liver function (AST, ALT, GGT, STB) in, HBV-DNA replication through 22 different levels, the difference was not statistically significant(P>0.05).Liver fibrosis in three, all the indicators in the HBV-DNA replication levels in different groups of each other, the difference was not statistically significant (P> 0.05), HBV-DNA can not replicate that degree of liver fibrosis.Conclusion:1. We can draw a clear conclusion:the Stagnation of liver-energy and spleen deficiency type is the most common in our clinical study.The retention of evil wetness-heat type, accumulated blood stasis type, the liver and the kidney yin-deficiency type, and the spleen and the kidney yang-deficiency type are respective are the different stages of chronic hepatitis B with HBeAg negative. When the disease become worse, the lever of examination increased, but the case decreased.2.It had high relationship between the syndrome of accumulated blood stasis type and hepatic fibrosis in chronic hepatitis B with HBeAg negative.