Matched Case-control Study For Detecting Risk Factors Of Breast Cancer In Women Living In The Four Cities

Objective Although there were many qualitative conclusions in the risk of breast cancer, there were other factors to be discussing . Especially, in different countries, different cities, there were many different risks to occur breast cancer and in the similar risks, the effective intensities were not similar either. This study was to investigate if there were local features in the risk of breast cancer to conduct properly preventing this kind of cancer. At the same time, to explore the distribution of estrogen receptor (ER) and progesterone receptor(PR) in breast cancer patients . Methods A matched case-control study which according to the cooperation center of the tumor hospital of the academe of Chinese medical science demand was performed in 300 cases with breast cancer who lived in this area. At same time, we analyze the same cases (Beijing city, Wuhan city. Guangzhou city) supported by this center, using the Spss statistic software. Results The common risk factors for the combined data of the four cities were high educational level, high body mass index, high intake of milk products, high intake of eggs, history of benign diseases, old age at marriage,dysmenorrhea, short duration of lactation. Among these factors, different cities had different ORs. Statistically significant correlations existed in Beijing, such as the pollution of environment, the carcinoid of breast, the high quantity of intake of milk products and intake of eggs every month were its dangerous factors, eating shallot and garlic food could prevent breast cancer perfectly. In Wuhan city, high educational level, high body mass index, the history of women's procreation system diseases, short duration of lactations were its dangerous factors, the protection factors were the same as Beijing. In Guangzhou city, high educational level, high body mass index, the cancer of the family history were its risk factors and the older ages of menarche, more ages of contraception were its protection factors. In Xinxiang city, such as passive smoking were remarkable risk factors and the protection factors were the same as Beijing. In addition, the correlation coefficient between ER and PR was positive (P<0.0001). The ER negative expression in patients aged 39or younger was significantly higher than other age groups (p<0.0001).Conclusion Calling for the movement of giving up smoking not only preventing the lung cancer, the cardiovascular disease, but also having an important meaning to prevent women breast cancer in Xinxiang city. At one time, the habit of eating shallot and garlic food should be carried forward. In addition, the positive and negative distribution of ER and PR has certain regular patterns and may be as the marker to select the combining therapy and estimate the prognosis in breast cancer patients.