Clinical Study On Treatment Of Cancer Pain With Traditional Chinese Medicine

Objective:This topic to cancer pain NRS score and quality of life volume table QLQ-C30 as observation indexes, objective evaluation of traditional Chinese medicine analgesic powder in clinical curative effect, for traditional Chinese medicine external treatment characteristic advantage in improving the cancer pain and improve the quality of life of patients and provide evidence for clinic.Method:According to the unbalanced index minimum principle of distribution was observed in 36 cases of malignant neuropathic pain patients, were randomly divided into treatment group (on the umbilicus and fentanyl) and control group (fentanyl),18 cases in each. Patients in control group were treated by transdermal fentanyl patch than4.2mg, Q72h; the treatment group in the control group on the basis of traditional Chinese medicine combined with analgesic plaster, replaced once a day, two groups were observed 7 days. The two groups of patients were filled with cancer pain NRS scale, the frequency of pain, the total dose of opioid drugs, respectively, in the treatment of first days, eighth days to fill out the QLQ-C30 scale, through the SPSS20.0 for statistical analysis.Result:1. The pain relief degree:treatment group and control group before and after treatment in patients with pain score of NRS decreased, treatment group NRS score by 7.00±1.17 fell to 3.00±1.27, before and after treatment compared with statistical significance (P<0.05); control group NRS score by 7.41±1.06 to 3.05±1.29, before and after treatment compared with statistical significance (P<0.05);The total effective rate of pain in the treatment group was 70.59%,64.71% in control group, pain between the two groups of efficiency, there was no significant difference (P>0.05). Before and after the treatment, the outbreak of pain frequency and treatment group by 3.18±1.33 reduced to 1.06±0.82 times, statistical significance (P> 0.05); by3.12±1.22 variable for 2.65±0.61 in the control group, no statistical significance (P> 0.05),the comparison between the two groups after treatment,P<0.05, statistical significance.Total dose of opioid drugs during treatment, the treatment group is less than the control group, with statistical significance (P< 0.05).2. Opioid dosage:Day 1 and day 8 opioid drug dose treatment, treatment dose group (159.41±16.97) mg reduced to (138.82±55.43) mg before and after treatment compared with statistical significance (P< 0.05); control group dose by 165.88±17.95 mg to 211.76±46.40 mg, before and after treatment in comparison with statistical significance (P< 0.05). Between the eighth days of the group of opioid doses, P< 0.05, there was statistical significance.3. Quality of life (QOL) table:Treatment group before and after treatment in the tired, nausea and vomiting, pain, insomnia, loss of appetite, constipation, total quality of life standards in the field of comparative and statistical significance (P< 0.05); control group before and after treatment in fatigue, pain, general quality of life standards in the field of comparative and statistical significance (P< 0.05), nausea, vomiting, insomnia, loss of appetite, constipation standards in the field of points before and after the treatment, no statistical significance (P> 0.05); group compared two groups in physical function, fatigue, insomnia symptoms, and overall quality of life standards in the field of comparison, P> 0.05, no statistically significant.4. Safety index:After treatment in the two groups blood routine, liver and kidney function indexes had no significantly abnormal changes; umbilical skin no redness, itching, pain, ulceration.Conclusion:Zhongyaozhitong powder and fentanyl transdermal patches in the treatment of malignant neuropathic pain has synergistic effect;Zhongyaozhitong powder can reduce fentanyl transdermal patches dose and reduce the number of pain broke out; Zhongyaozhitong powder alleviate of neuropathic cancer pathological pain correlation of fatigue,gastrointestinal symptoms and sleep disorders in a certain extent, so as to improve the patients’ quality of life.