Study On The Effect Of Acupuncturing On The Local Consistency Of Cortex In Patients With Non - Aura Migraine

Background:As a clinical common primary headache, the repeated migraine attacks seriously affect patients’daily life. Previous studies have shown that acupuncture treatment on migraine is efficacious. Zulinqi (GB41) is effective and widely used in clinical practice of migraine treatment. With the use of functional magnetic resonance imaging (fMRI) technology, related experiment researches have attained rich results.Objective:In current study, we designed an fMRI research on migraine without aura (MWoA), compared with healthy subjects. The objective is to investigate the characteristics of the cortical regional homogeneity (ReHo) on migraine and the effects of needling manipulation in GB41.Methods:A total of 10 MWoA patients and 10 age- and gender-matched healthy control (HC) subjects were recruited in our study. Both MWoA and HC subjects were scannedby fMRI on the resting state and needling manipulation in GB41. Then fMRI data is projected to the cortical models. After applying SPM8 software ect, we calculated the regional homogeneity based on cortex. The specified abnormal changes and the modulatory effects of GB41 in the ReHo based on cortex of MWoA patients were explored in contrast to HC subjects.Results:During the resting-state, the cortical ReHo of MWoA patients compared with HC subjects showed decrease in right middle occipital gyrus, superior occipital gyrus, cuneus, precuneus and calcarine cortex, and increase in bilateral orbital superior frontal gyrus, orbital middle frontal gyrus, medial orbital frontal gyrus, gyrus rectus, left medial superior frontal gyrus and right orbital inferior frontal gyrus.Under the instant effects of needling in GB41, HC subjects showed significantly decreased cortical ReHo values in left middle frontal gyrus, superior frontal gyrus, precentral gyrus, while MWoA patients showed significant decrease in left middle frontal gyrus, superior frontal gyrus, inferior frontal triangle. Analysis of interactions revealed right lingual as the specified cortex between MWoA patients and HC subjects during needling in GB41.Conclusion:The results of our study demonstrated that there are specified abnormal changes in the right occipital cortex and bilateral prefrontal cortex of MWoA patients contrasted to HC subjects. Moreover, the acupuncture in GB41 could modulate dorsolateral prefrontal cortex in both groups. However, the modulation in right lingual has remarkable difference between MWoA patients and HC subjects.