Analysis Of Curative Effect Of Yiqi And Xuefang Combined With Entecavir In The Treatment Of Hypersplenism Of Hepatitis B Cirrhosis

ObjectiveThe tetrospective study to analysis of the clinical efficacy of Yiqihexue prescription joint Entecavir in the treatment of hypersplenism causing by hepatitis B cirrhosis, discuss the effective method with Chinese combined Western medicine for the trearment of hypersplenism causing by hepatitis B cirrhosis, provide clinical evidence for combined Chinese and Western medicine treatment.MethodsThe collection of cases in line with Western medicine hypersplenism causing by hepatitis B cirrhosis diagnosis and TCM qi deficiency,bleeding resistance of the permit patients,from outpatients of Beijing Hospital of Traditional Chinese Medicine Affiliated Captial Medical University from September 2010 to March 2014.The total of 100 cases were followed up time more than two years. According to different treatment,divided two groups,60 cases in the treatment group who used Yiqihexue prescription joint Entecavir,40 cases in the control group with Fufangbiejiaruangan tablet joint Entecavir treatment, we observated 24 months,and recorded before the treatmen, treatment of 6 months,12 months,24 months symptoms,and signs Laboratory indicators of blood count, liver function,prothrombin activity (PTA), HBV-DNA, aspartate aminotransferase to platelet ratio index (APRI), and the poral vein diameter, apleen size data.Establish a database,applicate the statistical software SPSS 17.0 to analyze date.Results1.Two groups of patients with gender, age, white blood cell, blood platelet, Seru m alanine aminotransferase(ALT), aspartate aminotransferase(AST), glutamyl glutamyl(G GT),total bilirubin (TBiL),serum albumin(ALB), prothrombin activity(PTA),HBV-DNA, and aspartate aminotransferase to platelet ratio index (APRI), there was no significantl y different before trearment;2.Both two groups had a clinically significant improvement in symptoms after the treatments and had significant difference between them(P<0.01),treatment group symptoms and effective improved better than control group after treatment 24 months(P<0.01);3.The countings of white blood cell and platelet were increaded in two groups after the treatments (P<0.01), the indicator of treatment group inclined better than control group after treatment 24 months(P<0.01),and had significant difference between them(P<0.01).Both two groups had no significant improvement in RBC count after the treatments(P>0.01),-4.Two groups of patients Serum alanine aminotransferase(ALT), aspartate aminotransferase(AST), serum albumin(ALB), these indicators better than those before treatment were significantly different(P<0.05), and the treatment group compared with ontrol group, treatment group can significantly reduce ALT,AST, increase ALB.(P<0.01). Treatment group had a significantly decreased in GGT,TBiLand alkaline phosphatase(ALP) (P<0.01) compared with pro-treatment,while control group had no significant difference(P> 0.01).Both two groups had a significant improvement in PTA, after the treatments and had significant difference between them(P< 0.01),the indicator of treatment group improved better than control group after treatment 24 months(P<0.01);5.Two group of patients APRI were decline after treatment,the treatment group before and after treatment had a statiscally significant(P<0.01),but the control group had not significant difference(P>0.01), the indicator of treatment group inclined better than control group after treatment 24 months(P<0.01);6.Two groups of HBV-DNA in drops after 24 month of treatment, but had no ddifference between them(P>0.01);7.The size of spleen and the diameters of portal vein had a significant reducing after the treatments in both groups,and had a significant difference between them(P<0.01).ConclusionYiqihexue prescription joint Entecavir in the treatment of hypersplenism causing by hepatitis B cirrhosis can give full play to the advantages of TCM,increased WBC,PLT, PTA, improved liver function,APRI, and reduced the size of spleen beteer than Fufangbiejiaruangan tablet joint Entecavir treatment,can improve the patients clinical symptoms and quality of lives, is worthy of application and popularization of a new way of thinking and trearment method.