Retrospective Analysis Of The Effect Of Infusion Of Fresh Frozen Plasma On Coagulation Function In Patients With Intraoperative Blood Loss

Objective:This research is mainly to study the clinical intraoperative massive hemorrhage patient’s coagulation function. Through adding the infusion of fresh frozen plasma, it is to study whether the patient’s coagulation function are improved or not,and in order to guide transfusion therapy clinical patients with massive hemorrhage.Methods:Select the patient of the second affiliated hospital of Kunming Medical University in November 2014 and January 2014, intraoperative blood loss during 3000-4000 ml.According to the quantity of fresh frozen plasma transfused during surgery were divided into A, B,C three groups,group A for the input of fresh frozen plasma (fresh-frozen plasma, FFP) 600 ml,group B for the input of fresh frozen plasma 900 ml, fresh frozen plasma for input group C 1200-1500 ml.Fresh frozen plasma infusion with different capacity were compared in patients with the change of PT, PT/13s, APTT, APTT/40s,FIB and INR before and after surgery Among them, PT/13s refers to the ratio of the actual value of PT and standard 13s, APTT/40s refers to the ratio of the actual value of APTT and standard 40s.Statisting the proportion of patients with surgical bleeding, compare the relation of surgical bleeding incidence among A, B, C three groups.The standard of surgical bleeding is PT (actual value)/13s≥1.5 times, APTT (actual value)/40s≥2 times, FIB< 2 g/L, INR≥1.5.Observed in patients who were not infused platelets, platelet changes before and after operation.Results:Patients with intraoperative blood loss, input 600ml FFP (group A, n =17).PT extension was 19.37±4.08 s,PT/13 was 1.49±0.31, PT/INR was 1.61± 0.37,43.8% of the cases of PT/131.5 or higher,50.0% of cases INR 1.5 or higher, 31.3% of cases FIB< 2.0 g/L. Input 900 ml FFP (group B, n=16), the INR was 1.47 ±0.28,43.8% of the cases of PT/13 1.5 or higher,50.0% of cases INR 1.5 or higher, 31.3% of cases FIB< 2.0 g/L;Input 1200-1500ml FFP (group C, n=8),12.5% of the cases of PT/13 and INR 1.5 or higher and FIB< 2.0 g/L.Intraoperative blood loss, 3000-4000 ml of 48 cases, the platelet count operative 215.2±83.7 x109/L fell to 100.3±45.1x109/L.Conclusion:1.Patients with blood loss,3000-4000 ml, after infusion FFP600 or 900 ml, the risk of bleeding, such as infusion FFP1200-1500 ml, low risk of bleeding.2. Blood loss in patients with 3000-4000 ml, platelet were not transfused among during an operation,but platelet is in the range of normal after an operation.So platelet need not be transfused.