Voltage Characteristics Of Small Biomolecules And Epinephrine Interaction And Theoretical Research

Small biological molecules are basic elements of large biological molecules, and also the important participants in the activities of life. The ultimate goal of the biological activity of large molecules are often metabolism of small chemical elements. Adrenaline is an important neurotransmitter of mammals and human beings, which controls both the nervous system to carry out a series of biological reactions and nerve chemical processes. Adrenaline is also a kind of biological molecules. To study the interaction between small biological molecules and adrenaline can propel the development of biology, pharmaceutical chemistry and physical chemistry, etc. In the present thesis, the interaction of hydrogen bond between adrenaline and small biological molecules has been investigated by means of electrochemistry and quantum chemistry.In this paper we choose some typical biological molecules to carry out the experiments,such as glycine, formamide, formic acid, ethanoic acid, phosphoric acid, boric acid and the corresponding acid groups. Cyclic voltammetry was performed to study the effect of small biological molecules on the cyclic voltammetric properties of adrenaline in different mediums. The results indicate that small biological molecules have stabilization on adrenaline, so that the ability of oxidation of adrenaline decreases, which alters the cyclic voltammetric properties of adrenaline.The results show that the electron-transfer nature of adrenaline is related not only to the pH value of the solution,also to the composition of it. Different buffer solutions with the same pH value have different influence on adrenaline's electron-transfer because they contain different anions.The hydrogen bonding complexes can be formed between small biologicalmolecules and adrenaline. The quantum studies are carried out in this thesis. The geometries of adrenaline and the stable complexes are respectively optimized to obtain structural parameters and binding energies. The calculation results can be better used to explain some experimental phenomena.