Preparation Of Gossypol Acetic Acid

As a kind of male prophylactic, gossypol acetic acid has been applied comprehensive in many fields, such as medicine chemical engineering and technical engineering. Based on integrated national inside and outside literatures, this paper studies aniline-acetone method feasibility and obtains great development in reducing costs increasing yield and optimizing technical conditions. In this experiment, the content of free gossypol is 1.066% determined by AOCS method which was laid down by American Oil Chemistry Society; When preparing aniline gossypol, the optional technological conditions are obtained: 80% acetone solution, the ratio solvent(ml) to cottonseed(g) is 2:1, socking twice and lasting 4 hours. The overall yield of aniline gossypol can reach 83%; When manufacturing gossypol acetic acid starting from aniline ossypol, it is pointed out that the ther Once Translation is more preferable than cetone Twice Translation?with even yield 68% while the former has predigested reaction approach and reduced cost, whose superiority is approved. Antioxidant S has been used when acetone is being solvent. Water also has been antioxidant process when ether is being solvent in twice refined acetic acid gossypol. All these methods succeed to settling the problems that gossypol is oxidized easily. Qualified product has been obtained whose pureness is closed to 100% in HPLC. The general yield is about 45.0% improved greatly compared with literatures. Finally, based on summing up all literatures and experiments, a new distill and preparation method olumniation Separation has been founded. It has particular advantage in preparing trifle products not only without the presence of toxicant-aniline but also without refined. This new experiment will exploit a new way in preparing and refining ossypol acetic acid. The ultimately product has been verified qualified through kinds of analytical instruments, such as TLC.. IV.. HPLC.