| Much significant research has taken place about derivant of amino acid complexes, especially its coordination chemistry owing to amino acid's important and potential application in biology field. In this thesis, we designed and synthesized first row transition metal coordination for researching relationship between their activities and structures. 19 derivants of amino acid were synthesized by the reactions of benzoyl chloride, 2-chlorobenzoyl chloride, 2,3,4,5-tetrafluorobenzoyl chloride, 3,5-dibromo-2-hydroxybenzaldehyde with various amino acids. 15 complexes were synthesized by these derivants of amino acid and 4,4'-bipy,2,2'-bipy,l,10-phen and first row transition metal. These compounds were characterized by elemental analysis, IR, and x-ray. 5 single crystal structures of the derivants of amino acid and 15 complexes were determined, and their variations on structure and property were also discussed. The thesis contains the following works.First, 14 kinds of derivant of amino acid ligands were synthesized by the following method: benzoyl chloride, 2-chlorobenzoyl chloride, and 2,3,4,5-tetrafluorobenzoyl chloride, react with various amino acids in the alkalescent solution. Among the 14 kinds of ligands, the crystal structures of 2-benzamidoacetic acid (HL1), 2-(2-chlorobenzamido) acetic acid (HL2), 2-(2-chlorobenzamido)-3-hydroxypropanoic acid(HL3), 2-(2,3,4,5-tetrafluorobenzamido)propanoic acid (HL11),3-hydroxy-2-(2,3,4,5-tetrafluorobenzamido)propanoic acid (HL12) were resolved. 12 metal complexes, such as Cu2(L1)4(H2O)4·H2O(1A), Cu2(L1)4(4,4'-bipyMH2O)2(2A), (L2)6Zn3(H2O)2·4(C2H6O)(1B), (L10)2Cu(H2O)2·2(H2O)(1C), and so on, were synthesized with the method of volatilizing in room temperature and hydrothermal approach .The crystal structures of all the 12 complexes were resolved and their coordination mode and structural features were discussed by combining spectroscopic analysis. 2A is a kind of multinuclear complex, which have distinctive scalar structure. 1B is a kind of trinuclear complex and 1A is binuclear complex. (L2)2Cu(H2O)( 2,2-bipy)·H2O(2B), 1C -8C are mononuclear complexes, and have strongΠ-Πdeposition efficiency in 2B. In addition, hydrogen bonding of the complexes play important roles in linking the layers of the network structure.Second, 4 kinds of derivant of amino acid ligands were synthesized by the following method: 3,5-dibromo-2-hydroxybenzaldehyde react with various amino acids. In the chapter, 2 complexes((L15)Ni(H2O)3(1D),(L15)2Zn2(H2O)2(2D)) were synthesized with the method of volatilizing in room temperature and hydrothermal approach . The crystal structures of lD(mononuclaer) and 2D(multinuclear) were resolved and their coordination mode and structural features were discussed by combining spectroscopic analysis. In the compounds 1D and 2D,the centre atoms have different coordination geometries. Hydrogen bonding of the complexes make 1D into 1-D catenoid structure and 2D is 3-D structure. Moreover, 1 kind of derivant of amino acid ligands were synthesized by the reaction of schiff base which were synthesized from hydroxybenzaldehyde and Gly, and NaBH4.(?) complex 3D (multinuclear) were synthesized with the ligand , 2,2-bipy and Cu2+.2D and 3D have the structure of catenulate in the form of Z.Third, the bacteriostatic power on Escherichia coli and the catalytic power to acyloin condensation and the interaction of several typical tribasic complexes with DNA were measured and obtained good results. The data of the first experiment indicated that theses compounds have good antibacterial activities, and the data of the second experiment showed that the tribasic complexes interact with DNA mainly by groovate mode. |
PDF Full Text Request