Qufeng Interest Pain Cream Extraction Process

Qufengxitong Plaster is extracted and processed from 20 kinds of traditional Chinese medicines, including Zushima, Chinese angelica root, red peony root, cyperus tuber and so on. It has the functions of muscles relaxation and blood promotion and expelling pathogenic wind, and has the effective therapeutic functions for arthralgia, myalgia, numbness of limbs, wind-warm pathogen, rheumatic arthritis, wound and etc. During the recent years, the scientific research on traditional Chinese medicine has developed rapidly. The traditional preparation and extraction method has been proved to affect the main components and the contents of the medicine to some extent. Based on the principle of "Modernization of Traditional Chinese Medicine", this topic discusses the systematic research on the preparation process of Zushima, furthermore, the topic has made the initial research on applying the high performance liquid chromatography as the quality standard of Chinese traditional medicine preparation.Traditional Chinese medicine immerse method contains Decoction Process,Immerse Method,Percolation Method,Recycling Extraction Method and so on. In this topic, the prescrition of Qufengxitong Plaster has 20 kinds of traditional Chinese medicines.The effective components of Ruixiangsu in Zushima, dissolving in boiling water and weak ethanol, combines with Cassia,Lilac, The root of Chinese wild ginger in the prescrition, etc. and the physico-chemical qualities of other effective components, referring some reported documents, Percolation Method is supposed to be the optimum extraction method. Percolation Method benefits the extraction of many medicinal materials and it also suits the full extraction when there are less effective components in medicinal materials. It avoids the shortcomings in other extraction methods in which some volatile oil is losed because of being heated. It also shows good results in soaking, high extraction degree, convenient operation and reasonable economy. At the same time, ethanol, often used as a solvent in Percolation Method, has been determined to be the best infusion,which has many advantages of economy, poisonless and fit for industrial production as well.This topic has first investigated and made an experiment in single factor, and determined the condensation of ethanol, quantitity of use, immerse time and range of percolation speed. Meanwhile, through the orthogonal test experiment, the best extraction process has been chosen.Lastly, ethanol density is determined to be 60%, the quanitity of ethanol 8 times more than the one of medicinal materials, immerse time for 8 hours, percolation speed 6ml/min·kg. This process is supposed to be the best technological one.By applying HPLC, this topic has made the research on the analysis of percolation extraction liquid. Under the condition of mobile phase-Acetonitrile-0.2% Phosphoric acid (14:86) and 327nm testing wavelength, the main contents of Ruixiangsu in Zushima has been determined. The thin layer chromatography (TLC) has been also applied in 8 kinds of medicinal materials, including Chinese angelica rrot, cassia, Red peony root and so on. The test results show TLC method is feasible and stabile.The best extraction technology on Qufengxitong Plaster is gained in the topic and the methods of qualitation and quantitation on the extract are set up by HPLC and TLC.